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DURECT - 25 Year Stock Price History | DRRX

Historical daily share price chart and data for DURECT since 2000 adjusted for splits and dividends. The latest closing stock price for DURECT as of June 09, 2025 is 0.55.
  • The all-time high DURECT stock closing price was 158.12 on November 06, 2000.
  • The DURECT 52-week high stock price is 1.84, which is 234.5% above the current share price.
  • The DURECT 52-week low stock price is 0.48, which is 12.7% below the current share price.
  • The average DURECT stock price for the last 52 weeks is 1.05.
For more information on how our historical price data is adjusted see the Stock Price Adjustment Guide.
  
DURECT Historical Annual Stock Price Data
Year Average Stock Price Year Open Year High Year Low Year Close Annual % Change
2025 0.7349 0.7908 0.8700 0.4999 0.5528 -26.29%
2024 1.1587 0.5550 1.7800 0.5215 0.7500 27.12%
2023 3.8218 3.6000 8.7200 0.5020 0.5900 -82.95%
2022 5.6450 9.7500 9.7500 3.3900 3.4600 -64.91%
2021 16.0516 21.0000 28.7000 8.9560 9.8590 -52.37%
2020 20.0734 26.1500 28.5000 9.6780 20.7000 -45.53%
2019 11.8597 5.4020 38.0000 5.1200 38.0000 686.59%
2018 14.2259 9.2020 25.1000 4.8310 4.8310 -47.59%
2017 12.6894 13.4000 21.0000 7.7580 9.2180 -31.21%
2016 13.7067 20.4000 20.4000 10.1000 13.4000 -39.37%
2015 20.0206 8.3000 32.3000 8.3000 22.1000 180.03%
2014 14.1437 17.3000 22.2000 6.9570 7.8920 -54.38%
2013 12.3986 9.6000 17.5000 7.7080 17.3000 88.04%
2012 9.5235 12.0000 16.6000 6.9410 9.2000 -22.03%
2011 24.2069 35.9000 37.3000 11.5000 11.8000 -65.80%
2010 25.9768 25.6000 36.1500 19.5000 34.5000 39.68%
2009 24.4710 33.0000 33.9000 14.4000 24.7000 -27.14%
2008 46.5304 62.1000 64.3000 28.7000 33.9000 -47.28%
2007 47.9036 43.9000 69.0000 36.8000 64.3000 44.82%
2006 44.8070 50.7000 63.6000 27.6000 44.4000 -12.43%
2005 46.1877 31.2000 71.8000 26.4000 50.7000 54.57%
2004 26.7017 26.4000 42.3000 12.6000 32.8000 31.20%
2003 24.3274 21.2000 40.0000 11.2000 25.0000 23.76%
2002 62.5330 110.5000 116.0000 19.7000 20.2000 -82.57%
2001 88.3904 111.2500 140.0000 40.0000 115.9000 -3.42%
Sector Industry Market Cap Revenue
Medical Medical - Drug Manufacturing $0.017B $0.002B
Durect Corp. is pioneering the treatment of chronic diseases and conditions by developing and commercializing pharmaceutical systems to deliver the right drug to the right place in the right amount at the right time. Its pharmaceutical systems combine engineering innovations and delivery technology from the medical device and drug delivery industries with its proprietary pharmaceutical and biotechnology drug formulations.
Stock Name Country Market Cap PE Ratio
Chugai Pharmaceutical (CHGCY) Japan $86.949B 32.62
Zoetis (ZTS) United States $75.757B 28.27
Takeda Pharmaceutical (TAK) Japan $47.602B 9.47
Daiichi Sankyo, - (DSNKY) Japan $45.824B 23.49
BeOne Medicines - (ONC) Cayman Islands $28.015B 0.00
Sandoz Group AG (SDZNY) Switzerland $23.544B 0.00
Merck (MKKGY) Germany $16.989B 12.45
Summit Therapeutics (SMMT) United States $15.291B 0.00
United Therapeutics (UTHR) United States $14.697B 13.00
Shionogi (SGIOY) Japan $14.292B 0.00
Neurocrine Biosciences (NBIX) United States $12.409B 42.51
IPSEN (IPSEY) France $10.165B 0.00
Orion OYJ (ORINY) Finland $10.083B 27.27
Corcept Therapeutics (CORT) United States $7.381B 60.00
Stevanato Group S.p.A (STVN) Italy $7.189B 43.96
Madrigal Pharmaceuticals (MDGL) United States $6.178B 0.00
Hikma Pharmaceuticals Plc (HKMPF) United Kingdom $6.153B 0.00
Grifols, S.A (GRFS) Spain $6.064B 0.00
Ionis Pharmaceuticals (IONS) United States $5.617B 0.00
Ono Pharmaceutical (OPHLF) Japan $4.913B 14.94
Soleno Therapeutics (SLNO) United States $3.805B 0.00
Catalyst Pharmaceuticals (CPRX) United States $3.156B 11.06
Crinetics Pharmaceuticals (CRNX) United States $3.091B 0.00
Hypermarcas (HYPMY) Brazil $2.958B 19.46
AMNEAL PHARMACEUTICALS, INC (AMRX) United States $2.388B 12.91
BioCryst Pharmaceuticals (BCRX) United States $2.310B 0.00
NewAmsterdam Pharma (NAMS) Netherlands $2.261B 0.00
Recursion Pharmaceuticals (RXRX) United States $2.232B 0.00
Indivior (INDV) United States $1.940B 8.23
Dyne Therapeutics (DYN) United States $1.671B 0.00
Centessa Pharmaceuticals (CNTA) United Kingdom $1.592B 0.00
Evotec AG (EVO) Germany $1.438B 0.00
Ocular Therapeutix (OCUL) United States $1.437B 0.00
ARS Pharmaceuticals (SPRY) United States $1.423B 0.00
Guardian Pharmacy Services (GRDN) United States $1.307B 0.00
Aurinia Pharmaceuticals Inc (AUPH) Canada $1.107B 22.14
Harrow (HROW) United States $1.086B 0.00
Akebia Therapeutics (AKBA) United States $1.043B 0.00
Enliven Therapeutics (ELVN) United States $1.018B 0.00
Collegium Pharmaceutical (COLL) United States $0.970B 5.23
Avadel Pharmaceuticals (AVDL) Ireland $0.940B 0.00
Ardelyx (ARDX) United States $0.880B 0.00
Cronos Group (CRON) Canada $0.764B 0.00
Xeris Biopharma Holdings (XERS) United States $0.716B 0.00
KalVista Pharmaceuticals (KALV) United States $0.714B 0.00
Xencor (XNCR) United States $0.687B 0.00
Liminatus Pharma (LIMN) United States $0.630B 0.00
Elite Pharmaceuticals (ELTP) United States $0.620B 0.00
AleAnna (ANNA) United States $0.617B 0.00
Relay Therapeutics (RLAY) United States $0.576B 0.00
Regulus Therapeutics (RGLS) United States $0.569B 0.00
Theravance Biopharma (TBPH) United States $0.563B 0.00
Verve Therapeutics (VERV) United States $0.552B 0.00
Bioventus (BVS) United States $0.550B 13.94
USANA Health Sciences (USNA) United States $0.547B 11.90
Zevra Therapeutics (ZVRA) United States $0.506B 0.00
Tourmaline Bio (TRML) United States $0.495B 0.00
Amylyx Pharmaceuticals (AMLX) United States $0.475B 0.00
Oruka Therapeutics (ORKA) United States $0.471B 0.00
Altimmune (ALT) United States $0.456B 0.00
Siga Technologies (SIGA) United States $0.431B 9.00
Savara (SVRA) United States $0.422B 0.00
Organogenesis (ORGO) United States $0.384B 0.00
Rigel Pharmaceuticals (RIGL) United States $0.384B 10.38
Aquestive Therapeutics (AQST) United States $0.354B 0.00
Heron Therapeutics (HRTX) United States $0.320B 0.00
Tonix Pharmaceuticals Holding (TNXP) United States $0.298B 0.00
ProKidney (PROK) United States $0.286B 0.00
Nature's Sunshine Products (NATR) United States $0.266B 24.59
Esperion Therapeutics (ESPR) United States $0.242B 0.00
MediWound (MDWD) Israel $0.233B 0.00
Nanobiotix S.A (NBTX) France $0.222B 0.00
4D Molecular Therapeutics (FDMT) United States $0.202B 0.00
Lyell Immunopharma (LYEL) United States $0.189B 0.00
OmniAb (OABI) United States $0.183B 0.00
Journey Medical (DERM) United States $0.172B 0.00
Larimar Therapeutics (LRMR) United States $0.172B 0.00
Profound Medical (PROF) Canada $0.167B 0.00
Aclaris Therapeutics (ACRS) United States $0.166B 0.00
Avita Medical (RCEL) United States $0.162B 0.00
Enanta Pharmaceuticals (ENTA) United States $0.160B 0.00
Aldeyra Therapeutics (ALDX) United States $0.159B 0.00
Inhibikase Therapeutics (IKT) United States $0.146B 0.00
Korro Bio (KRRO) United States $0.137B 0.00
Achieve Life Sciences (ACHV) Canada $0.133B 0.00
Lexeo Therapeutics (LXEO) United States $0.129B 0.00
Protara Therapeutics (TARA) United States $0.129B 0.00
Nektar Therapeutics (NKTR) United States $0.124B 0.00
Innate Pharma SA (IPHYF) France $0.122B 0.00
Wellgistics Health (WGRX) United States $0.121B 0.00
Cardiol Therapeutics (CRDL) Canada $0.117B 0.00
Corbus Pharmaceuticals Holdings (CRBP) United States $0.113B 0.00
Cassava Sciences (SAVA) United States $0.106B 0.00
Ironwood Pharmaceuticals (IRWD) United States $0.098B 0.00
Fractyl Health (GUTS) United States $0.097B 0.00
OptiNose (OPTN) United States $0.097B 0.00
Champions Oncology (CSBR) United States $0.095B 15.66
VAXART, INC (VXRT) United States $0.093B 0.00
Inotiv (NOTV) United States $0.092B 0.00
Unicycive Therapeutics (UNCY) United States $0.091B 0.00
Arch Biopartners (ACHFF) Canada $0.089B 0.00
Cumberland Pharmaceuticals (CPIX) United States $0.087B 64.67
Nutriband (NTRB) United States $0.086B 0.00
Pyxis Oncology (PYXS) United States $0.084B 0.00
Galectin Therapeutics (GALT) United States $0.084B 0.00
Dominari Holdings (DOMH) United States $0.079B 0.00
ESSA Pharma (EPIX) Canada $0.076B 0.00
Surrozen (SRZN) United States $0.073B 0.00
Vivani Medical (VANI) United States $0.068B 0.00
Metagenomi (MGX) United States $0.065B 0.00
Telomir Pharmaceuticals (TELO) United States $0.064B 0.00
Assertio Holdings (ASRT) United States $0.063B 0.00
Context Therapeutics (CNTX) United States $0.060B 0.00
Allergy Therapeutics (AGYTF) United Kingdom $0.059B 0.00
Prelude Therapeutics (PRLD) United States $0.058B 0.00
Gain Therapeutics (GANX) United States $0.058B 0.00
Verrica Pharmaceuticals (VRCA) United States $0.057B 0.00
NRx Pharmaceuticals (NRXP) United States $0.057B 0.00
Century Therapeutics (IPSC) United States $0.053B 0.00
PMV Pharmaceuticals (PMVP) United States $0.050B 0.00
Rafael Holdings (RFL) United States $0.047B 0.00
Avalo Therapeutics (AVTX) United States $0.044B 0.00
Mural Oncology (MURA) Ireland $0.044B 0.00
ElectroCore (ECOR) United States $0.043B 0.00
Acrivon Therapeutics (ACRV) United States $0.042B 0.00
Iterum Therapeutics (ITRM) Ireland $0.039B 0.00
Karyopharm Therapeutics (KPTI) United States $0.039B 0.00
Reviva Pharmaceuticals Holdings (RVPH) United States $0.038B 0.00
SCYNEXIS (SCYX) United States $0.036B 0.00
PolyPid (PYPD) Israel $0.033B 0.00
China SXT Pharmaceuticals (SXTC) China $0.033B 0.00
Lyra Therapeutics (LYRA) United States $0.032B 0.00
FibroGen (FGEN) United States $0.032B 0.00
Tempest Therapeutics (TPST) United States $0.030B 0.00
Relmada Therapeutics (RLMD) United States $0.028B 0.00
Jupiter Neurosciences (JUNS) United States $0.026B 0.00
CASI Pharmaceuticals (CASI) China $0.023B 0.00
Enlivex Therapeutics (ENLV) Israel $0.023B 0.00
Natural Alternatives (NAII) United States $0.021B 0.00
Mannatech (MTEX) United States $0.020B 0.00
BioVie (BIVI) United States $0.020B 0.00
MARKER THERAPEUTICS, INC (MRKR) United States $0.020B 0.00
BioLineRx (BLRX) Israel $0.019B 0.00
Lipocine (LPCN) United States $0.017B 0.00
VYNE Therapeutics (VYNE) United States $0.015B 0.00
ProPhase Labs (PRPH) United States $0.015B 0.00
TherapeuticsMD (TXMD) United States $0.014B 0.00
Phio Pharmaceuticals (PHIO) United States $0.014B 0.00
Scienture Holdings (SCNX) United States $0.014B 0.00
Ainos (AIMD) United States $0.014B 0.00
Cosmos Health (COSM) United States $0.014B 0.00
Vivos Therapeutics (VVOS) United States $0.013B 0.00
Minerva Neurosciences (NERV) United States $0.013B 2.24
GlycoMimetics (GLYC) United States $0.013B 0.00
Ernexa Therapeutics (ERNA) United States $0.011B 0.00
Addex Therapeutics (ADXN) Switzerland $0.011B 0.00
Mangoceuticals (MGRX) United States $0.011B 0.00
Talphera (TLPH) United States $0.010B 0.00
Kiora Pharmaceuticals (KPRX) United States $0.009B 0.00
Traws Pharma (TRAW) United States $0.009B 0.00
SHINECO (SISI) China $0.009B 0.00
Citius Pharmaceuticals (CTXR) United States $0.009B 0.00
Biomerica (BMRA) United States $0.009B 0.00
NLS Pharmaceutics (NLSP) Switzerland $0.008B 0.00
Carisma Therapeutics (CARM) United States $0.008B 0.00
Nuvilex (PMCB) United States $0.007B 0.00
Klotho Neurosciences (KLTO) United States $0.007B 0.00
XTL Biopharmaceuticals (XTLB) Israel $0.006B 0.00
TransCode Therapeutics (RNAZ) United States $0.006B 0.00
Aptorum Group (APM) United Kingdom $0.006B 0.00
Plus Therapeutics (PSTV) United States $0.006B 0.00
Indaptus Therapeutics (INDP) United States $0.006B 0.00
Sonoma Pharmaceuticals (SNOA) United States $0.005B 0.00
Incannex Healthcare (IXHL) Australia $0.005B 0.00
Quoin Pharmaceuticals (QNRX) United States $0.005B 0.00
Alaunos Therapeutics (TCRT) United States $0.005B 0.00
Redhill Biopharma (RDHL) Israel $0.005B 0.00
Xenetic Biosciences (XBIO) United States $0.005B 0.00
60 Degrees Pharmaceuticals (SXTP) United States $0.004B 0.00
PainReform (PRFX) Israel $0.004B 0.00
Jaguar Animal Health (JAGX) United States $0.004B 0.00
Clearmind Medicine (CMND) Canada $0.004B 0.00
Heatwurx (PCSA) United States $0.004B 0.00
CERo Therapeutics Holdings (CERO) United States $0.004B 0.00
XORTX Therapeutics (XRTX) Canada $0.003B 0.00
InMed Pharmaceuticals (INM) Canada $0.003B 0.00
SciSparc (SPRC) Israel $0.003B 0.00
Aditxt (ADTX) United States $0.003B 0.00
Qualigen Therapeutics (QLGN) United States $0.003B 0.00
Galmed Pharmaceuticals (GLMD) Israel $0.003B 0.00
TNF Pharmaceuticals (TNFA) United States $0.002B 0.00
Conduit Pharmaceuticals (CDT) United States $0.002B 0.00
Shuttle Pharmaceuticals Holdings (SHPH) United States $0.002B 0.00
Salarius Pharmaceuticals (SLRX) United States $0.002B 0.00
Universe Pharmaceuticals INC (UPC) China $0.000B 0.00
4D Pharma (LBPS) United Kingdom $0.000B 0.00
MEI Pharma (MEIP) United States $0.000B 0.00
Patheon (PTHN) Netherlands $0.000B 0.00
RVL Pharmaceuticals (RVLP) United States $0.000B 0.00
Silence Therapeutics (SLN) United Kingdom $0.000B 0.00