Ionis Pharmaceuticals - 15 Year Stock Price History | IONS

Historical daily share price chart and data for Ionis Pharmaceuticals since 2011 adjusted for splits and dividends. The latest closing stock price for Ionis Pharmaceuticals as of September 18, 2026 is 44.44.

The all-time high Ionis Pharmaceuticals stock closing price was 86.50 on February 06, 2026.
The Ionis Pharmaceuticals 52-week high stock price is 86.74, which is 95.2% above the current share price.
The Ionis Pharmaceuticals 52-week low stock price is 44.36, which is 0.2% below the current share price.
The average Ionis Pharmaceuticals stock price for the last 52 weeks is 72.09.

Ionis Pharmaceuticals Historical Annual Stock Price Data
Year	Average Stock Price	Year Open	Year High	Year Low	Year Close	Annual % Change
2026	71.2744	79.6700	86.5000	44.4400	44.4400	-43.83%
2025	47.7503	34.6900	82.7300	25.5100	79.1100	126.29%
2024	43.1008	52.8700	53.5500	33.7300	34.9600	-30.90%
2023	41.3095	37.5800	51.6300	33.5800	50.5900	33.94%
2022	38.7002	32.6000	48.6600	29.8800	37.7700	24.12%
2021	40.8556	56.7800	63.7800	25.6100	30.4300	-46.18%
2020	54.1692	60.8900	63.4000	41.6000	56.5400	-6.41%
2019	64.9707	53.7700	86.1400	52.9200	60.4100	11.75%
2018	48.2373	49.2500	59.5400	40.5300	54.0600	7.48%
2017	49.6931	47.3400	64.3900	37.9100	50.3000	5.16%
2016	35.8627	61.6800	61.6800	20.6200	47.8300	-22.77%
2015	59.1678	61.5700	77.0800	38.0400	61.9300	0.31%
2014	41.1384	39.8700	65.0900	22.9800	61.7400	54.97%
2013	25.5855	10.8200	41.6800	10.4900	39.8400	281.61%
2012	10.2666	7.2500	15.4100	7.0900	10.4400	44.80%

Sector	Industry	Market Cap	Revenue
Medical	Medical - Drug Manufacturing	$7.385B	$0.944B
Ionis Pharmaceuticals discovers/develops RNA-targeted therapeutics using its proprietary antisense oligonucleotide technology. Its antisense medicines have been developed/are being developed to treat neurological, cardiovascular and specialty rare diseases.

Stock Name	Country	Market Cap	PE Ratio
Chugai Pharmaceutical (CHGCY)	Japan	$70.766B	23.37
Takeda Pharmaceutical (TAK)	Japan	$60.592B	11.26
UCB SA (UCBJY)	Belgium	$45.206B	0.00
BeOne Medicines - (ONC)	Switzerland	$38.518B	61.77
Otsuka Holdings, - (OTSKY)	Japan	$37.978B	14.20
Sandoz Group AG (SDZNY)	Switzerland	$36.696B	0.00
Daiichi Sankyo, - (DSNKY)	Japan	$35.209B	21.98
Zoetis (ZTS)	United States	$29.504B	10.85
Astellas Pharma (ALPMY)	Japan	$27.471B	9.09
United Therapeutics (UTHR)	United States	$21.215B	17.70
Merck (MKKGY)	Germany	$19.225B	15.34
Shionogi (SGIOY)	Japan	$15.862B	9.32
IPSEN (IPSEY)	France	$15.003B	0.00
Neurocrine Biosciences (NBIX)	United States	$14.864B	20.20
Summit Therapeutics (SMMT)	United States	$14.240B	0.00
Orion OYJ (ORINY)	Finland	$13.312B	19.41
Madrigal Pharmaceuticals (MDGL)	United States	$12.280B	0.00
Recordati Industria Chimica E Farmaceutica S.P.A (RCDTF)	Italy	$11.965B	15.26
Corcept Therapeutics (CORT)	United States	$11.922B	262.60
Eisai (ESAIY)		$9.158B	0.00
Crinetics Pharmaceuticals (CRNX)	United States	$9.013B	0.00
Ono Pharmaceutical (OPHLF)	Japan	$7.049B	13.27
Stevanato Group S.p.A (STVN)	Italy	$6.572B	32.88
Oruka Therapeutics (ORKA)	United States	$6.287B	0.00
Centessa Pharmaceuticals (CNTA)	United Kingdom	$6.267B	0.00
AMNEAL PHARMACEUTICALS, INC (AMRX)	United States	$5.975B	21.76
Definium Therapeutics (DFTX)	United States	$5.215B	0.00
Grifols, S.A (GRFS)	Spain	$4.975B	0.00
Hikma Pharmaceuticals Plc (HKMPF)	United Kingdom	$4.923B	0.00
Relay Therapeutics (RLAY)	United States	$4.129B	0.00
Indivior Pharmaceuticals (INDV)	United States	$4.117B	9.56
Catalyst Pharmaceuticals (CPRX)	United States	$3.855B	11.93
Enliven Therapeutics (ELVN)	United States	$3.623B	0.00
Amylyx Pharmaceuticals (AMLX)	United States	$3.611B	0.00
Dyne Therapeutics (DYN)	United States	$3.195B	0.00
Hypermarcas (HYPMY)	Brazil	$3.172B	9.01
Soleno Therapeutics (SLNO)	United States	$2.717B	228.83
NewAmsterdam Pharma (NAMS)	Netherlands	$2.688B	0.00
Nektar Therapeutics (NKTR)	United States	$2.291B	0.00
Aurinia Pharmaceuticals Inc (AUPH)	Canada	$2.249B	16.57
Guardian Pharmacy Services (GRDN)	United States	$2.240B	42.44
BioCryst Pharmaceuticals (BCRX)	United States	$2.218B	5.99
Ocular Therapeutix (OCUL)	United States	$2.194B	0.00
Avadel Pharmaceuticals (AVDL)	Ireland	$2.113B	0.00
Xencor (XNCR)	United States	$1.838B	0.00
KARDIGAN INC (KARD)	United States	$1.556B	0.00
Xeris Biopharma Holdings (XERS)	United States	$1.495B	117.14
Harrow (HROW)	United States	$1.240B	0.00
Cronos Group (CRON)	Canada	$1.235B	30.45
Apnimed (APMD)		$1.207B	0.00
Aktis Oncology (AKTS)	United States	$1.176B	0.00
Seaport Therapeutics (SPTX)	United States	$1.145B	0.00
Savara (SVRA)	United States	$1.103B	0.00
Bioventus (BVS)	United States	$1.086B	16.99
KalVista Pharmaceuticals (KALV)	United States	$0.993B	0.00
Cybin (HELP)	Canada	$0.974B	0.00
Avalo Therapeutics (AVTX)	United States	$0.889B	0.00
Theravance Biopharma (TBPH)	United States	$0.884B	0.00
Rigel Pharmaceuticals (RIGL)	United States	$0.863B	11.90
Ardelyx (ARDX)	United States	$0.852B	0.00
4D Molecular Therapeutics (FDMT)	United States	$0.841B	0.00
Achieve Life Sciences (ACHV)	Canada	$0.821B	0.00
Esperion Therapeutics (ESPR)	United States	$0.819B	0.00
Aclaris Therapeutics (ACRS)	United States	$0.769B	0.00
Collegium Pharmaceutical (COLL)	United States	$0.741B	3.26
Silence Therapeutics (SLN)	United Kingdom	$0.735B	0.00
Ironwood Pharmaceuticals (IRWD)	United States	$0.720B	5.59
Zevra Therapeutics (ZVRA)	United States	$0.689B	7.35
OmniAb (OABI)	United States	$0.647B	0.00
Altimmune (ALT)	United States	$0.632B	0.00
Aquestive Therapeutics (AQST)	United States	$0.579B	0.00
ProKidney (PROK)	United States	$0.577B	0.00
Evotec AG (EVO)	Germany	$0.569B	0.00
Indaptus Therapeutics (INDP)	United States	$0.473B	0.00
Relmada Therapeutics (RLMD)	United States	$0.439B	0.00
ARS Pharmaceuticals (SPRY)	United States	$0.409B	0.00
Larimar Therapeutics (LRMR)	United States	$0.394B	0.00
Prelude Therapeutics (PRLD)	United States	$0.389B	0.00
Lexeo Therapeutics (LXEO)	United States	$0.345B	0.00
Avita Medical (RCEL)	United States	$0.339B	0.00
Century Therapeutics (IPSC)	United States	$0.337B	0.00
Inhibikase Therapeutics (IKT)	United States	$0.321B	0.00
Pyxis Oncology (PYXS)	United States	$0.278B	0.00
Lyell Immunopharma (LYEL)	United States	$0.270B	0.00
Elite Pharmaceuticals (ELTP)	United States	$0.267B	12.38
USANA Health Sciences (USNA)	United States	$0.261B	14.28
Galectin Therapeutics (GALT)	United States	$0.256B	0.00
Akebia Therapeutics (AKBA)	United States	$0.254B	0.00
Nature's Sunshine Products (NATR)	United States	$0.229B	11.13
Siga Technologies (SIGA)	United States	$0.226B	0.00
AleAnna (ANNA)	United States	$0.218B	17.21
Cardiol Therapeutics (CRDL)	Canada	$0.218B	0.00
Profound Medical (PROF)	Canada	$0.214B	0.00
Protara Therapeutics (TARA)	United States	$0.210B	0.00
Journey Medical (DERM)	United States	$0.206B	0.00
Surrozen (SRZN)	United States	$0.192B	0.00
Tonix Pharmaceuticals Holding (TNXP)	United States	$0.186B	0.00
Organogenesis (ORGO)	United States	$0.183B	0.00
Minerva Neurosciences (NERV)	United States	$0.175B	0.00
MediWound (MDWD)	Israel	$0.172B	0.00
Atrium Therapeutics (RNA)	United States	$0.153B	0.00
Korro Bio (KRRO)	United States	$0.148B	0.00
NRx Pharmaceuticals (NRXP)	United States	$0.144B	0.00
Corbus Pharmaceuticals Holdings (CRBP)	United States	$0.140B	0.00
Innate Pharma SA (IPHYF)	France	$0.138B	0.00
Unicycive Therapeutics (UNCY)	United States	$0.134B	0.00
VAXART, INC (VXRT)	United States	$0.118B	3.04
Assertio Holdings (ASRT)	United States	$0.116B	0.00
Cumberland Pharmaceuticals (CPIX)	United States	$0.110B	0.00
Vivani Medical (VANI)	United States	$0.107B	0.00
Rafael Holdings (RFL)	United States	$0.107B	0.00
ElectroCore (ECOR)	United States	$0.105B	0.00
Allergy Therapeutics (AGYTF)	United Kingdom	$0.103B	0.00
Cassava Sciences (SAVA)	United States	$0.101B	0.00
PolyPid (PYPD)	Israel	$0.099B	0.00
Nutriband (NTRB)	United States	$0.099B	0.00
Fractyl Health (GUTS)	United States	$0.096B	0.00
HST Global (HSTC)	United States	$0.092B	0.00
Telomir Pharmaceuticals (TELO)	United States	$0.085B	0.00
Aldeyra Therapeutics (ALDX)	United States	$0.082B	0.00
PMV Pharmaceuticals (PMVP)	United States	$0.080B	0.00
Acrivon Therapeutics (ACRV)	United States	$0.079B	0.00
Gain Therapeutics (GANX)	United States	$0.077B	0.00
Verrica Pharmaceuticals (VRCA)	United States	$0.076B	0.00
Champions Oncology (CSBR)	United States	$0.074B	0.00
Nuo Therapeutics (AURX)		$0.063B	0.00
Talphera (TLPH)	United States	$0.060B	0.00
Dominari Holdings (DOMH)	United States	$0.059B	0.00
Heron Therapeutics (HRTX)	United States	$0.059B	0.00
Veraxa Biotech AG (VRXA)	United States	$0.046B	0.00
SCYNEXIS (SCYX)	United States	$0.044B	0.00
Incannex Healthcare (IXHL)	Australia	$0.044B	0.00
Karyopharm Therapeutics (KPTI)	United States	$0.043B	0.00
FibroGen (FGEN)	United States	$0.039B	0.00
Lite Strategy (LITS)	United States	$0.038B	0.00
Mural Oncology (MURA)	Ireland	$0.035B	0.00
Context Therapeutics (CNTX)	United States	$0.034B	0.00
Cosmos Health (COSM)	United States	$0.032B	0.00
Optimi Health (OPTH)	Canada	$0.028B	0.00
TransCode Therapeutics (RNAZ)	United States	$0.028B	0.00
Plus Therapeutics (PSTV)	United States	$0.027B	0.00
TherapeuticsMD (TXMD)	United States	$0.025B	0.00
Universe Pharmaceuticals INC (UPC)	China	$0.024B	0.00
MARKER THERAPEUTICS, INC (MRKR)	United States	$0.020B	0.00
VYNE Therapeutics (VYNE)	United States	$0.019B	0.00
Lipocine (LPCN)	United States	$0.018B	0.00
Citius Pharmaceuticals (CTXR)	United States	$0.016B	0.00
Klotho Neurosciences (KLTO)	United States	$0.016B	0.00
Tempest Therapeutics (TPST)	United States	$0.016B	0.00
Vyome Holdings (HIND)	United States	$0.015B	0.00
Iterum Therapeutics (ITRM)	Ireland	$0.015B	0.00
Mannatech (MTEX)	United States	$0.014B	0.00
Quoin Pharmaceuticals (QNRX)	United States	$0.014B	0.00
Enlivex (ENLV)	Israel	$0.014B	0.00
BioVie (BIVI)	United States	$0.014B	0.00
Scienture Holdings (SCNX)	United States	$0.013B	0.00
Kiora Pharmaceuticals (KPRX)	United States	$0.012B	0.00
BioLineRx (BLRX)	Israel	$0.012B	0.00
Phio Pharmaceuticals (PHIO)	United States	$0.012B	0.00
Natural Alternatives (NAII)	United States	$0.012B	0.00
CASI Pharmaceuticals (CASI)	China	$0.010B	0.00
Mangoceuticals (MGRX)	United States	$0.010B	0.00
Wellgistics Health (WGRX)	United States	$0.009B	0.00
Inotiv (NOTV)	United States	$0.008B	0.00
Biomerica (BMRA)	United States	$0.008B	0.00
Traws Pharma (TRAW)	United States	$0.008B	0.00
Curanex Pharmaceuticals Inc (CURX)	United States	$0.007B	0.00
Xenetic Biosciences (XBIO)	United States	$0.006B	0.00
Ernexa Therapeutics (ERNA)	United States	$0.006B	0.00
Sonoma Pharmaceuticals (SNOA)	United States	$0.006B	0.00
XTL Biopharmaceuticals (XTLB)	Israel	$0.006B	0.00
Heatwurx (PCSA)	United States	$0.005B	0.00
Nuvilex (PMCB)	United States	$0.005B	0.00
Salarius Pharmaceuticals (SLRX)	United States	$0.005B	0.00
Galmed Pharmaceuticals (GLMD)	Israel	$0.005B	0.00
Liminatus Pharma (LIMN)	United States	$0.005B	0.00
InMed Pharmaceuticals (INM)	Canada	$0.005B	0.00
Aptorum Group (APM)	United Kingdom	$0.004B	0.00
Addex Therapeutics (ADXN)	Switzerland	$0.004B	0.00
Niki BioSolutions (NIKI)	United Kingdom	$0.004B	0.00
Galmed Pharmaceuticals (EOCN)	Israel	$0.004B	0.00
XORTX Therapeutics (XRTX)	Canada	$0.003B	0.00
Redhill Biopharma (RDHL)	Israel	$0.003B	0.00
60 Degrees Pharmaceuticals (SXTP)	United States	$0.003B	0.00
Alaunos Therapeutics (TCRT)	United States	$0.003B	0.00
Jupiter Neurosciences (JUNS)	United States	$0.003B	0.00
SciSparc (SPRC)	Israel	$0.003B	0.00
Vivos Therapeutics (VVOS)	United States	$0.002B	0.00
Shuttle Pharmaceuticals Holdings (SHPH)	United States	$0.002B	0.00
China SXT Pharmaceuticals (SXTC)	China	$0.001B	0.00
Jaguar Animal Health (JAGX)	United States	$0.001B	0.00
PainReform (PRFX)	Israel	$0.001B	0.00
Clearmind Medicine (CMND)	Canada	$0.001B	0.00
CDT Equity (CDT)	United States	$0.000B	0.00
Emisphere Technologies (EMIS)	United States	$0.000B	0.00
4D Pharma (LBPS)	United Kingdom	$0.000B	0.00
Patheon (PTHN)	Netherlands	$0.000B	0.00
RVL Pharmaceuticals (RVLP)	United States	$0.000B	0.00