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Ionis Pharmaceuticals Return on Investment 2011-2025 | IONS

Current and historical return on investment (ROI) values for Ionis Pharmaceuticals (IONS) over the last 10 years.
Ionis Pharmaceuticals ROI - Return on Investment Historical Data
Date TTM Net Income LT Investments & Debt Return on Investment
2025-09-30 $-0.28B $1.21B -18.44%
2025-06-30 $-0.27B $1.26B -15.91%
2025-03-31 $-0.47B $1.73B -27.22%
2024-12-31 $-0.48B $1.83B -28.19%
2024-09-30 $-0.37B $1.90B -22.71%
2024-06-30 $-0.37B $1.50B -23.42%
2024-03-31 $-0.39B $1.53B -24.00%
2023-12-31 $-0.35B $1.62B -21.34%
2023-09-30 $-0.56B $1.60B -32.85%
2023-06-30 $-0.47B $1.74B -26.89%
2023-03-31 $-0.47B $1.66B -26.18%
2022-12-31 $-0.41B $1.76B -22.12%
2022-09-30 $0.02B $1.84B 0.94%
2022-06-30 $-0.01B $1.87B -0.47%
2022-03-31 $0.00B $1.96B 0.21%
2021-12-31 $-0.03B $2.00B -1.68%
2021-09-30 $-0.27B $1.77B -16.83%
2021-06-30 $-0.23B $1.82B -12.57%
2021-03-31 $-0.20B $1.55B -10.55%
2020-12-31 $-0.17B $1.37B -8.09%
2020-09-30 $0.11B $2.42B 4.60%
2020-06-30 $0.15B $2.40B 6.43%
2020-03-31 $0.18B $2.37B 8.08%
2019-12-31 $0.37B $2.47B 16.71%
2019-09-30 $0.12B $2.15B 5.75%
2019-06-30 $0.10B $2.12B 5.10%
2019-03-31 $0.06B $2.04B 3.78%
2018-12-31 $-0.06B $1.82B -4.26%
2018-09-30 $-0.08B $1.46B -6.40%
2018-06-30 $-0.05B $1.44B -4.35%
2018-03-31 $0.01B $1.00B 0.86%
2017-12-31 $0.03B $0.97B 3.49%
2017-09-30 $0.10B $1.00B 13.37%
2017-06-30 $0.11B $0.75B 16.30%
2017-03-31 $0.05B $0.73B 8.77%
2016-12-31 $-0.02B $0.62B -3.73%
2016-09-30 $-0.15B $0.56B -25.61%
2016-06-30 $-0.22B $0.52B -35.25%
2016-03-31 $-0.12B $0.56B -18.48%
2015-12-31 $-0.08B $0.72B -11.00%
2015-09-30 $0.00B $0.65B -0.30%
2015-06-30 $0.03B $0.69B 4.00%
2015-03-31 $-0.03B $0.66B -4.63%
2014-12-31 $-0.05B $0.64B -8.72%
2014-09-30 $-0.08B $0.50B -14.89%
2014-06-30 $-0.08B $0.53B -15.45%
2014-03-31 $-0.08B $0.53B -15.41%
2013-12-31 $-0.05B $0.54B -10.39%
2013-09-30 $-0.06B $0.56B -12.89%
2013-06-30 $-0.06B $0.56B -15.35%
2013-03-31 $-0.05B $0.35B -14.57%
2012-12-31 $-0.07B $0.33B -21.54%
2012-09-30 $-0.06B $0.32B -19.58%
2012-06-30 $-0.06B $0.31B -17.52%
2012-03-31 $-0.07B $0.30B -22.44%
2011-12-31 $-0.07B $0.32B -20.71%
2011-09-30 $-0.07B $0.33B -18.93%
2011-06-30 $-0.06B $0.36B -14.72%
2011-03-31 $-0.06B $0.37B -15.61%
2010-12-31 $-0.05B $0.38B -12.37%
2010-09-30 $-0.05B $0.39B -10.97%
2010-06-30 $-0.05B $0.40B -10.87%
2010-03-31 $-0.03B $0.42B -7.38%
2009-12-31 $-0.03B $0.44B -6.39%
2009-09-30 $-0.02B $0.44B -6.05%
2009-06-30 $-0.01B $0.44B -4.05%
2009-03-31 $-0.01B $0.43B -2.73%
2008-12-31 $-0.01B $0.28B -5.44%
2008-09-30 $-0.01B $0.24B -3.31%
2008-06-30 $0.00B $0.23B 1.55%
2008-03-31 $-0.02B $0.22B -9.46%
2007-12-31 $-0.03B $0.16B -17.19%
2007-09-30 $-0.05B $0.17B -22.36%
2007-06-30 $-0.07B $0.21B -37.63%
2007-03-31 $-0.07B $0.23B -39.72%
2006-12-31 $-0.07B $0.20B -42.62%
2006-09-30 $-0.06B $0.14B -43.48%
2006-06-30 $-0.05B $0.14B -38.43%
2006-03-31 $-0.05B $0.13B -37.11%
2005-12-31 $-0.06B $0.14B -42.34%
2005-09-30 $-0.10B $0.15B -71.00%
2005-06-30 $-0.11B $0.12B -69.92%
2005-03-31 $-0.12B $0.14B -63.38%
2004-12-31 $-0.12B $0.16B -53.24%
2004-09-30 $-0.09B $0.21B -34.54%
2004-06-30 $-0.08B $0.24B -31.12%
2004-03-31 $-0.08B $0.27B -28.92%
2003-12-31 $-0.08B $0.28B -26.31%
2003-09-30 $-0.07B $0.28B -21.77%
2003-06-30 $-0.07B $0.30B -20.39%
2003-03-31 $-0.06B $0.33B -17.03%
2002-12-31 $-0.05B $0.35B -14.45%
2002-09-30 $-0.05B $0.35B -13.59%
2002-06-30 $-0.04B $0.38B -10.72%
2002-03-31 $-0.04B $0.34B -14.31%
2001-12-31 $-0.05B $0.35B -20.40%
2001-09-30 $-0.05B $0.24B -26.04%
2001-06-30 $-0.04B $0.16B -26.17%
2001-03-31 $-0.03B $0.15B -21.12%
2000-12-31 $-0.03B $0.17B -18.93%
2000-09-30 $-0.03B $0.16B -23.87%
2000-06-30 $-0.04B $0.16B -35.12%
2000-03-31 $-0.05B $0.14B -47.37%
1999-12-31 $-0.04B $0.09B -56.58%
1999-09-30 $-0.04B $0.08B -56.55%
1999-06-30 $-0.03B $0.08B -41.33%
1999-03-31 $-0.03B $0.06B -40.26%
1998-12-31 $-0.03B $0.07B -36.81%
1998-09-30 $-0.03B $0.09B -33.82%
1998-06-30 $-0.03B $0.09B -38.55%
1998-03-31 $-0.03B $0.08B -35.91%
1997-12-31 $-0.03B $0.09B -34.50%
1997-09-30 $-0.01B $0.08B -13.33%
1997-06-30 $-0.02B $0.08B -20.69%
1997-03-31 $-0.01B $0.07B -18.25%
1996-12-31 $0.00B $0.08B 1.87%
1996-09-30 $-0.01B $0.07B -22.12%
1996-06-30 $-0.01B $0.07B -24.30%
1996-03-31 $-0.01B -25.40%
1995-12-31 $-0.02B $0.08B -40.34%
1995-09-30 $-0.03B $0.06B -47.17%
1995-06-30 $-0.02B $0.05B -43.40%
1995-03-31 $-0.02B $0.05B -38.10%
1994-12-31 $-0.02B $0.06B -26.88%
1994-09-30 $-0.02B $0.06B -22.64%
1994-06-30 $-0.01B $0.07B -21.96%
1994-03-31 $-0.01B $0.07B -22.86%
1993-12-31 $-0.02B $0.07B -30.77%
1993-09-30 $-0.02B $0.05B -35.51%
1993-06-30 $-0.02B $0.06B -37.38%
1993-03-31 $-0.02B $0.06B -35.19%
1992-12-31 $-0.02B $0.05B -35.19%
1992-06-30 $-0.01B $0.06B -22.12%
1992-03-31 $-0.01B $0.06B -20.41%
Sector Industry Market Cap Revenue
Medical Medical - Drug Manufacturing $11.589B $0.705B
Ionis Pharmaceuticals discovers/develops RNA-targeted therapeutics using its proprietary antisense oligonucleotide technology. Its antisense medicines have been developed/are being developed to treat neurological, cardiovascular and specialty rare diseases.
Stock Name Country Market Cap PE Ratio
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Takeda Pharmaceutical (TAK) Japan $45.470B 9.28
BeOne Medicines - (ONC) Switzerland $43.363B 212.69
Daiichi Sankyo, - (DSNKY) Japan $42.699B 21.26
Sandoz Group AG (SDZNY) Switzerland $30.385B 0.00
United Therapeutics (UTHR) United States $20.082B 17.67
Merck (MKKGY) Germany $17.810B 10.98
Shionogi (SGIOY) Japan $14.955B 13.73
Neurocrine Biosciences (NBIX) United States $14.443B 34.66
Summit Therapeutics (SMMT) United States $13.904B 0.00
IPSEN (IPSEY) France $12.822B 0.00
Madrigal Pharmaceuticals (MDGL) United States $12.019B 0.00
Orion OYJ (ORINY) Finland $9.803B 28.01
Eisai (ESAIY) $8.586B 0.00
Corcept Therapeutics (CORT) United States $7.946B 85.84
Stevanato Group S.p.A (STVN) Italy $6.687B 37.42
Grifols, S.A (GRFS) Spain $5.989B 0.00
Ono Pharmaceutical (OPHLF) Japan $5.204B 15.83
Hikma Pharmaceuticals Plc (HKMPF) United Kingdom $4.586B 0.00
NewAmsterdam Pharma (NAMS) Netherlands $4.349B 0.00
Crinetics Pharmaceuticals (CRNX) United States $4.049B 0.00
Centessa Pharmaceuticals (CNTA) United Kingdom $3.711B 0.00
AMNEAL PHARMACEUTICALS, INC (AMRX) United States $3.659B 17.37
Hypermarcas (HYPMY) Brazil $3.040B 20.87
Procaps Group, S.A (PROCF) Luxembourg $2.926B 0.00
Catalyst Pharmaceuticals (CPRX) United States $2.849B 9.09
Dyne Therapeutics (DYN) United States $2.684B 0.00
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Ocular Therapeutix (OCUL) United States $2.407B 0.00
Avadel Pharmaceuticals (AVDL) Ireland $2.301B 0.00
Aurinia Pharmaceuticals Inc (AUPH) Canada $2.024B 23.98
Guardian Pharmacy Services (GRDN) United States $1.850B 35.62
Harrow (HROW) United States $1.511B 92.71
BioCryst Pharmaceuticals (BCRX) United States $1.491B 88.50
Collegium Pharmaceutical (COLL) United States $1.453B 7.20
Ardelyx (ARDX) United States $1.424B 0.00
Amylyx Pharmaceuticals (AMLX) United States $1.394B 0.00
Oruka Therapeutics (ORKA) United States $1.311B 0.00
Enliven Therapeutics (ELVN) United States $1.310B 0.00
Xeris Biopharma Holdings (XERS) United States $1.191B 0.00
Nektar Therapeutics (NKTR) United States $1.153B 0.00
Relay Therapeutics (RLAY) United States $1.090B 0.00
Evotec AG (EVO) Germany $1.074B 0.00
Xencor (XNCR) United States $1.066B 0.00
Cronos Group (CRON) Canada $0.938B 0.00
Theravance Biopharma (TBPH) United States $0.881B 37.00
Savara (SVRA) United States $0.875B 0.00
ARS Pharmaceuticals (SPRY) United States $0.812B 0.00
Organogenesis (ORGO) United States $0.774B 0.00
Rigel Pharmaceuticals (RIGL) United States $0.761B 6.80
Elite Pharmaceuticals (ELTP) United States $0.725B 0.00
ProKidney (PROK) United States $0.709B 0.00
Esperion Therapeutics (ESPR) United States $0.693B 0.00
KalVista Pharmaceuticals (KALV) United States $0.688B 0.00
Lexeo Therapeutics (LXEO) United States $0.660B 0.00
Aquestive Therapeutics (AQST) United States $0.658B 0.00
4D Molecular Therapeutics (FDMT) United States $0.616B 0.00
Bioventus (BVS) United States $0.608B 12.46
Ironwood Pharmaceuticals (IRWD) United States $0.510B 12.08
Zevra Therapeutics (ZVRA) United States $0.500B 0.00
Akebia Therapeutics (AKBA) United States $0.443B 0.00
Altimmune (ALT) United States $0.435B 0.00
Siga Technologies (SIGA) United States $0.430B 5.88
Nature's Sunshine Products (NATR) United States $0.370B 22.05
Lyell Immunopharma (LYEL) United States $0.359B 0.00
Galectin Therapeutics (GALT) United States $0.355B 0.00
USANA Health Sciences (USNA) United States $0.351B 9.79
Silence Therapeutics (SLN) United Kingdom $0.323B 0.00
Aldeyra Therapeutics (ALDX) United States $0.304B 0.00
Larimar Therapeutics (LRMR) United States $0.280B 0.00
Avalo Therapeutics (AVTX) United States $0.274B 0.00
Aclaris Therapeutics (ACRS) United States $0.273B 0.00
Pyxis Oncology (PYXS) United States $0.271B 0.00
Achieve Life Sciences (ACHV) Canada $0.233B 0.00
OmniAb (OABI) United States $0.225B 0.00
AleAnna (ANNA) United States $0.220B 0.00
Protara Therapeutics (TARA) United States $0.213B 0.00
Journey Medical (DERM) United States $0.208B 0.00
Profound Medical (PROF) Canada $0.207B 0.00
MediWound (MDWD) Israel $0.202B 0.00
Heron Therapeutics (HRTX) United States $0.202B 0.00
Innate Pharma SA (IPHYF) France $0.168B 0.00
China SXT Pharmaceuticals (SXTC) China $0.153B 0.00
Tonix Pharmaceuticals Holding (TNXP) United States $0.139B 0.00
Corbus Pharmaceuticals Holdings (CRBP) United States $0.136B 0.00
Cassava Sciences (SAVA) United States $0.133B 0.00
Relmada Therapeutics (RLMD) United States $0.131B 0.00
Incannex Healthcare (IXHL) Australia $0.123B 0.00
Unicycive Therapeutics (UNCY) United States $0.122B 0.00
Avita Medical (RCEL) United States $0.114B 0.00
Inhibikase Therapeutics (IKT) United States $0.114B 0.00
Surrozen (SRZN) United States $0.111B 0.00
Context Therapeutics (CNTX) United States $0.107B 0.00
Vivani Medical (VANI) United States $0.104B 0.00
Gain Therapeutics (GANX) United States $0.103B 0.00
Cardiol Therapeutics (CRDL) Canada $0.101B 0.00
VAXART, INC (VXRT) United States $0.097B 0.00
Karyopharm Therapeutics (KPTI) United States $0.097B 0.00
Prelude Therapeutics (PRLD) United States $0.096B 0.00
Champions Oncology (CSBR) United States $0.094B 34.00
Dominari Holdings (DOMH) United States $0.080B 0.00
Assertio Holdings (ASRT) United States $0.076B 0.00
PMV Pharmaceuticals (PMVP) United States $0.073B 0.00
Lite Strategy (LITS) United States $0.072B 0.00
Acrivon Therapeutics (ACRV) United States $0.071B 0.00
Plus Therapeutics (PSTV) United States $0.070B 0.00
Nutriband (NTRB) United States $0.066B 0.00
Metagenomi (MGX) United States $0.065B 0.00
Fractyl Health (GUTS) United States $0.063B 0.00
Rafael Holdings (RFL) United States $0.063B 0.00
BioNxt Solutions (BNXTF) Canada $0.062B 0.00
Talphera (TLPH) United States $0.058B 0.00
Wellgistics Health (WGRX) United States $0.058B 0.00
Korro Bio (KRRO) United States $0.057B 0.00
PolyPid (PYPD) Israel $0.057B 0.00
NRx Pharmaceuticals (NRXP) United States $0.049B 0.00
Jupiter Neurosciences (JUNS) United States $0.047B 0.00
Telomir Pharmaceuticals (TELO) United States $0.046B 0.00
ElectroCore (ECOR) United States $0.045B 0.00
Century Therapeutics (IPSC) United States $0.041B 0.00
Tempest Therapeutics (TPST) United States $0.040B 0.00
Verrica Pharmaceuticals (VRCA) United States $0.037B 0.00
Mural Oncology (MURA) Ireland $0.036B 0.00
Inotiv (NOTV) United States $0.035B 0.00
FibroGen (FGEN) United States $0.035B 0.00
Reviva Pharmaceuticals Holdings (RVPH) United States $0.035B 0.00
Klotho Neurosciences (KLTO) United States $0.033B 0.00
Cumberland Pharmaceuticals (CPIX) United States $0.032B 26.38
Liminatus Pharma (LIMN) United States $0.029B 0.00
Vyome Holdings (HIND) United States $0.027B 0.00
Scienture Holdings (SCNX) United States $0.026B 0.00
Cosmos Health (COSM) United States $0.025B 0.00
SCYNEXIS (SCYX) United States $0.025B 0.00
Enlivex Therapeutics (ENLV) Israel $0.024B 0.00
TherapeuticsMD (TXMD) United States $0.023B 0.00
Iterum Therapeutics (ITRM) Ireland $0.023B 0.00
Natural Alternatives (NAII) United States $0.020B 0.00
Mannatech (MTEX) United States $0.018B 0.00
Vivos Therapeutics (VVOS) United States $0.018B 0.00
Traws Pharma (TRAW) United States $0.017B 0.02
Heatwurx (PCSA) United States $0.017B 0.00
Citius Pharmaceuticals (CTXR) United States $0.017B 0.00
Lipocine (LPCN) United States $0.016B 0.00
Mangoceuticals (MGRX) United States $0.016B 0.00
CASI Pharmaceuticals (CASI) China $0.016B 0.00
MARKER THERAPEUTICS, INC (MRKR) United States $0.015B 0.00
BioLineRx (BLRX) Israel $0.014B 0.00
Quoin Pharmaceuticals (QNRX) United States $0.013B 0.00
VYNE Therapeutics (VYNE) United States $0.012B 0.00
Ernexa Therapeutics (ERNA) United States $0.012B 0.00
ProPhase Labs (PRPH) United States $0.012B 0.00
BioVie (BIVI) United States $0.011B 0.00
Ainos (AIMD) United States $0.011B 0.00
Addex Therapeutics (ADXN) Switzerland $0.009B 0.00
Kiora Pharmaceuticals (KPRX) United States $0.008B 0.00
TransCode Therapeutics (RNAZ) United States $0.008B 0.00
Phio Pharmaceuticals (PHIO) United States $0.007B 0.00
Aptorum Group (APM) United Kingdom $0.007B 0.00
Biomerica (BMRA) United States $0.007B 0.00
Alaunos Therapeutics (TCRT) United States $0.007B 0.00
Lyra Therapeutics (LYRA) United States $0.007B 0.00
Sonoma Pharmaceuticals (SNOA) United States $0.006B 0.00
Nuvilex (PMCB) United States $0.005B 0.00
XTL Biopharmaceuticals (XTLB) Israel $0.005B 0.00
InMed Pharmaceuticals (INM) Canada $0.005B 0.00
Qualigen Therapeutics (QLGN) United States $0.005B 0.00
Xenetic Biosciences (XBIO) United States $0.004B 0.00
XORTX Therapeutics (XRTX) Canada $0.004B 0.00
Jaguar Animal Health (JAGX) United States $0.004B 0.00
60 Degrees Pharmaceuticals (SXTP) United States $0.004B 0.00
Redhill Biopharma (RDHL) Israel $0.004B 0.00
CDT Equity (CDT) United States $0.003B 0.00
Indaptus Therapeutics (INDP) United States $0.003B 0.00
Shuttle Pharmaceuticals Holdings (SHPH) United States $0.002B 0.00
Universe Pharmaceuticals INC (UPC) China $0.002B 0.00
PainReform (PRFX) Israel $0.002B 0.00
Galmed Pharmaceuticals (GLMD) Israel $0.002B 0.00
Clearmind Medicine (CMND) Canada $0.002B 0.00
SciSparc (SPRC) Israel $0.001B 0.00
Salarius Pharmaceuticals (SLRX) United States $0.001B 0.00
Aditxt (ADTX) United States $0.000B 0.00
Curanex Pharmaceuticals Inc (CURX) United States $0.000B 0.00
Emisphere Technologies (EMIS) United States $0.000B 0.00
Indivior (INDV) United States $0.000B 15.56
4D Pharma (LBPS) United Kingdom $0.000B 0.00
Minerva Neurosciences (NERV) United States $0.000B 0.00
Patheon (PTHN) Netherlands $0.000B 0.00
RVL Pharmaceuticals (RVLP) United States $0.000B 0.00