Ionis Pharmaceuticals Debt to Equity Ratio 2012-2026 | IONS

Current and historical debt to equity ratio values for Ionis Pharmaceuticals (IONS) over the last 10 years. The debt/equity ratio can be defined as a measure of a company's financial leverage calculated by dividing its long-term debt by stockholders' equity. Ionis Pharmaceuticals debt/equity for the three months ending June 30, 2026 was 3.07.
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Ionis Pharmaceuticals Debt/Equity Ratio Historical Data
Date Long Term Debt Shareholder's Equity Debt to Equity Ratio
2026-06-30 $2.56B $0.44B 5.81
2026-03-31 $2.96B $0.49B 6.02
2025-12-31 $3.04B $0.49B 6.21
2025-09-30 $2.42B $0.62B 3.91
2025-06-30 $2.35B $0.63B 3.73
2025-03-31 $2.34B $0.48B 4.91
2024-12-31 $2.42B $0.59B 4.11
2024-09-30 $2.42B $0.66B 3.65
2024-06-30 $2.43B $0.26B 9.21
2024-03-31 $2.47B $0.30B 8.32
2023-12-31 $2.60B $0.39B 6.73
2023-09-30 $2.62B $0.32B 8.30
2023-06-30 $2.54B $0.43B 5.94
2023-03-31 $2.40B $0.49B 4.93
2022-12-31 $1.96B $0.57B 3.42
2022-09-30 $1.83B $0.59B 3.08
2022-06-30 $1.83B $0.63B 2.93
2022-03-31 $1.81B $0.71B 2.55
2021-12-31 $1.84B $0.77B 2.38
2021-09-30 $1.88B $0.53B 3.55
2021-06-30 $1.91B $0.58B 3.29
2021-03-31 $1.57B $0.68B 2.30
2020-12-31 $1.65B $0.74B 2.22
2020-09-30 $1.49B $1.61B 0.93
2020-06-30 $1.48B $1.60B 0.93
2020-03-31 $1.52B $1.57B 0.97
2019-12-31 $1.55B $1.69B 0.92
2019-09-30 $1.40B $1.50B 0.93
2019-06-30 $1.42B $1.46B 0.98
2019-03-31 $1.45B $1.39B 1.04
2018-12-31 $1.48B $1.19B 1.25
2018-09-30 $1.41B $0.84B 1.68
2018-06-30 $1.43B $0.82B 1.75
2018-03-31 $0.91B $0.39B 2.36
2017-12-31 $0.96B $0.37B 2.62
2017-09-30 $0.86B $0.40B 2.15
2017-06-30 $0.88B $0.22B 4.06
2017-03-31 $0.88B $0.20B 4.37
2016-12-31 $0.81B $0.10B 8.17
2016-09-30 $0.70B $0.14B 5.04
2016-06-30 $0.70B $0.11B 6.29
2016-03-31 $0.72B $0.16B 4.54
2015-12-31 $0.75B $0.20B 3.72
2015-09-30 $0.74B $0.25B 3.03
2015-06-30 $0.68B $0.30B 2.25
2015-03-31 $0.68B $0.28B 2.46
2014-12-31 $0.70B $0.26B 2.71
2014-09-30 $0.45B $0.35B 1.30
2014-06-30 $0.45B $0.37B 1.23
2014-03-31 $0.46B $0.37B 1.23
2013-12-31 $0.47B $0.38B 1.24
2013-09-30 $0.48B $0.40B 1.20
2013-06-30 $0.39B $0.40B 0.97
2013-03-31 $0.35B $0.20B 1.75
2012-12-31 $0.36B $0.18B 1.99
2012-09-30 $0.32B $0.17B 1.85
2012-06-30 $0.32B $0.15B 2.06
2012-03-31 $0.32B $0.15B 2.12
2011-12-31 $0.31B $0.17B 1.83
2011-09-30 $0.32B $0.19B 1.71
2011-06-30 $0.32B $0.21B 1.50
2011-03-31 $0.28B $0.23B 1.22
2010-12-31 $0.31B $0.25B 1.25
2010-09-30 $0.32B $0.25B 1.27
2010-06-30 $0.34B $0.26B 1.31
2010-03-31 $0.32B $0.28B 1.11
2009-12-31 $0.36B $0.30B 1.18
2009-09-30 $0.38B $0.31B 1.23
2009-06-30 $0.40B $0.31B 1.32
2009-03-31 $0.42B $0.30B 1.39
2008-12-31 $0.43B $0.15B 2.89
2008-09-30 $0.52B $0.07B 7.59
2008-06-30 $0.55B $0.06B 9.33
2008-03-31 $0.35B $0.06B 6.42
2007-12-31 $0.26B $0.00B 295.86
2007-09-30 $0.21B $0.00B 917.12
2007-06-30 $0.22B $0.05B 4.57
2007-03-31 $0.29B $0.06B 5.15
2006-12-31 $0.19B $0.07B 2.73
2006-09-30 $0.19B $0.00B 118.07
2006-06-30 $0.20B $0.01B 29.08
2006-03-31 $0.16B $-0.01B -19.48
2005-12-31 $0.16B $0.00B 61.43
2005-09-30 $0.17B $0.00B 42.91
2005-06-30 $0.27B $-0.12B -2.18
2005-03-31 $0.28B $-0.10B -2.69
2004-12-31 $0.28B $-0.07B -3.89
2004-09-30 $0.27B $-0.02B -15.47
2004-06-30 $0.27B $0.01B 23.11
2004-03-31 $0.27B $0.05B 5.58
2003-12-31 $0.27B $0.07B 3.99
2003-09-30 $0.26B $0.09B 2.78
2003-06-30 $0.26B $0.11B 2.29
2003-03-31 $0.28B $0.13B 2.09
2002-12-31 $0.28B $0.16B 1.82
2002-09-30 $0.25B $0.17B 1.49
2002-06-30 $0.26B $0.19B 1.38
2002-03-31 $0.20B $0.20B 0.97
2001-12-31 $0.19B $0.22B 0.87
2001-09-30 $0.18B $0.12B 1.49
2001-06-30 $0.14B $0.05B 3.08
2001-03-31 $0.12B $0.04B 2.67
2000-12-31 $0.12B $0.07B 1.76
2000-09-30 $0.11B $0.07B 1.68
2000-06-30 $0.11B $0.07B 1.54
2000-03-31 $0.10B $0.05B 2.17
1999-12-31 $0.10B $0.00B 118.87
1999-09-30 $0.10B $-0.01B -11.12
1999-06-30 $0.10B $-0.01B -19.29
1999-03-31 $0.10B $-0.02B -6.28
1998-12-31 $0.10B $0.00B -23.99
1998-09-30 $0.10B $0.01B 8.01
1998-06-30 $0.11B $0.01B 8.27
1998-03-31 $0.08B $0.03B 3.11
1997-12-31 $0.08B $0.04B 2.38
1997-09-30 $0.06B $0.04B 1.35
1997-06-30 $0.06B $0.04B 1.36
1997-03-31 $0.05B $0.05B 0.92
1996-12-31 $0.04B $0.06B 0.74
1996-09-30 $0.03B $0.06B 0.41
1996-06-30 $0.03B $0.07B 0.39
1996-03-31 $0.00B 0.00
1995-12-31 $0.02B $0.08B 0.31
1995-09-30 $0.03B $0.05B 0.50
1995-06-30 $0.02B $0.04B 0.53
1995-03-31 $0.02B $0.04B 0.49
1994-12-31 $0.02B $0.05B 0.45
1994-09-30 $0.02B $0.05B 0.38
1994-06-30 $0.02B $0.06B 0.29
1994-03-31 $0.02B $0.06B 0.27
1993-12-31 $0.02B $0.06B 0.35
1993-09-30 $0.02B $0.04B 0.38
1993-06-30 $0.01B $0.05B 0.29
1993-03-31 $0.01B $0.05B 0.27
1992-12-31 $0.02B $0.04B 0.39
1992-09-30 $0.02B $0.05B 0.35
1992-06-30 $0.02B $0.05B 0.30
1992-03-31 $0.01B $0.05B 0.27
1991-12-31 $0.02B $0.06B 0.25
1991-09-30 $0.01B $0.03B 0.30
1991-06-30 $0.01B $0.03B 0.30
1990-12-31 $0.00B $0.00B 1.47
1989-12-31 $0.00B $0.00B 0.24
Sector Industry Market Cap Revenue
Medical Medical - Drug Manufacturing $7.852B $0.944B
Ionis Pharmaceuticals discovers/develops RNA-targeted therapeutics using its proprietary antisense oligonucleotide technology. Its antisense medicines have been developed/are being developed to treat neurological, cardiovascular and specialty rare diseases.
Stock Name Country Market Cap PE Ratio
Chugai Pharmaceutical (CHGCY) Japan $68.396B 22.59
Takeda Pharmaceutical (TAK) Japan $59.919B 11.13
UCB SA (UCBJY) Belgium $45.739B 0.00
Otsuka Holdings, - (OTSKY) Japan $39.680B 14.84
BeOne Medicines - (ONC) Switzerland $38.041B 61.00
Sandoz Group AG (SDZNY) Switzerland $35.464B 0.00
Daiichi Sankyo, - (DSNKY) Japan $34.072B 21.27
Zoetis (ZTS) United States $30.343B 11.16
Astellas Pharma (ALPMY) Japan $26.892B 8.90
United Therapeutics (UTHR) United States $21.460B 17.90
Merck (MKKGY) Germany $19.487B 15.54
Shionogi (SGIOY) Japan $15.947B 9.37
IPSEN (IPSEY) France $15.395B 0.00
Neurocrine Biosciences (NBIX) United States $15.249B 20.72
Summit Therapeutics (SMMT) United States $13.881B 0.00
Orion OYJ (ORINY) Finland $12.984B 18.93
Madrigal Pharmaceuticals (MDGL) United States $12.089B 0.00
Corcept Therapeutics (CORT) United States $11.979B 263.86
Recordati Industria Chimica E Farmaceutica S.P.A (RCDTF) Italy $11.965B 15.26
Crinetics Pharmaceuticals (CRNX) United States $9.013B 0.00
Eisai (ESAIY) $8.924B 0.00
Ono Pharmaceutical (OPHLF) Japan $7.049B 13.27
Stevanato Group S.p.A (STVN) Italy $6.523B 32.64
Centessa Pharmaceuticals (CNTA) United Kingdom $6.267B 0.00
Oruka Therapeutics (ORKA) United States $6.105B 0.00
AMNEAL PHARMACEUTICALS, INC (AMRX) United States $5.317B 19.36
Grifols, S.A (GRFS) Spain $5.009B 0.00
Definium Therapeutics (DFTX) United States $4.947B 0.00
Hikma Pharmaceuticals Plc (HKMPF) United Kingdom $4.923B 0.00
Relay Therapeutics (RLAY) United States $4.157B 0.00
Indivior Pharmaceuticals (INDV) United States $4.039B 9.38
Enliven Therapeutics (ELVN) United States $3.910B 0.00
Catalyst Pharmaceuticals (CPRX) United States $3.855B 11.93
Amylyx Pharmaceuticals (AMLX) United States $3.694B 0.00
Dyne Therapeutics (DYN) United States $3.343B 0.00
Hypermarcas (HYPMY) Brazil $3.203B 9.10
Soleno Therapeutics (SLNO) United States $2.717B 228.83
NewAmsterdam Pharma (NAMS) Netherlands $2.529B 0.00
Guardian Pharmacy Services (GRDN) United States $2.390B 45.28
Nektar Therapeutics (NKTR) United States $2.275B 0.00
Ocular Therapeutix (OCUL) United States $2.238B 0.00
Aurinia Pharmaceuticals Inc (AUPH) Canada $2.146B 15.81
Avadel Pharmaceuticals (AVDL) Ireland $2.113B 0.00
BioCryst Pharmaceuticals (BCRX) United States $2.085B 5.63
Xencor (XNCR) United States $1.766B 0.00
KARDIGAN INC (KARD) United States $1.735B 0.00
Xeris Biopharma Holdings (XERS) United States $1.366B 107.00
Harrow (HROW) United States $1.269B 0.00
Seaport Therapeutics (SPTX) United States $1.229B 0.00
Aktis Oncology (AKTS) United States $1.204B 0.00
Cronos Group (CRON) Canada $1.179B 29.09
Bioventus (BVS) United States $1.093B 17.10
Savara (SVRA) United States $1.081B 0.00
KalVista Pharmaceuticals (KALV) United States $0.993B 0.00
Cybin (HELP) Canada $0.992B 0.00
Theravance Biopharma (TBPH) United States $0.885B 0.00
Avalo Therapeutics (AVTX) United States $0.862B 0.00
Ardelyx (ARDX) United States $0.847B 0.00
Rigel Pharmaceuticals (RIGL) United States $0.821B 11.32
Esperion Therapeutics (ESPR) United States $0.819B 0.00
Aclaris Therapeutics (ACRS) United States $0.773B 0.00
Achieve Life Sciences (ACHV) Canada $0.753B 0.00
4D Molecular Therapeutics (FDMT) United States $0.753B 0.00
Silence Therapeutics (SLN) United Kingdom $0.750B 0.00
Apnimed (APMD) $0.711B 0.00
Collegium Pharmaceutical (COLL) United States $0.711B 3.13
Zevra Therapeutics (ZVRA) United States $0.692B 7.37
Ironwood Pharmaceuticals (IRWD) United States $0.671B 5.21
OmniAb (OABI) United States $0.630B 0.00
Altimmune (ALT) United States $0.628B 0.00
Aquestive Therapeutics (AQST) United States $0.604B 0.00
Evotec AG (EVO) Germany $0.580B 0.00
ProKidney (PROK) United States $0.526B 0.00
Indaptus Therapeutics (INDP) United States $0.485B 0.00
Relmada Therapeutics (RLMD) United States $0.474B 0.00
ARS Pharmaceuticals (SPRY) United States $0.423B 0.00
Larimar Therapeutics (LRMR) United States $0.406B 0.00
Prelude Therapeutics (PRLD) United States $0.361B 0.00
Century Therapeutics (IPSC) United States $0.359B 0.00
Lexeo Therapeutics (LXEO) United States $0.339B 0.00
Inhibikase Therapeutics (IKT) United States $0.322B 0.00
Avita Medical (RCEL) United States $0.314B 0.00
Pyxis Oncology (PYXS) United States $0.278B 0.00
USANA Health Sciences (USNA) United States $0.275B 15.05
Elite Pharmaceuticals (ELTP) United States $0.268B 12.44
Lyell Immunopharma (LYEL) United States $0.267B 0.00
Akebia Therapeutics (AKBA) United States $0.250B 0.00
Galectin Therapeutics (GALT) United States $0.246B 0.00
Nature's Sunshine Products (NATR) United States $0.230B 11.17
AleAnna (ANNA) United States $0.226B 17.84
Protara Therapeutics (TARA) United States $0.222B 0.00
Cardiol Therapeutics (CRDL) Canada $0.215B 0.00
Siga Technologies (SIGA) United States $0.214B 0.00
Journey Medical (DERM) United States $0.208B 0.00
Profound Medical (PROF) Canada $0.208B 0.00
Korro Bio (KRRO) United States $0.207B 0.00
Surrozen (SRZN) United States $0.206B 0.00
Tonix Pharmaceuticals Holding (TNXP) United States $0.199B 0.00
Organogenesis (ORGO) United States $0.188B 0.00
Minerva Neurosciences (NERV) United States $0.183B 0.00
MediWound (MDWD) Israel $0.173B 0.00
Atrium Therapeutics (RNA) United States $0.173B 0.00
NRx Pharmaceuticals (NRXP) United States $0.147B 0.00
Innate Pharma SA (IPHYF) France $0.138B 0.00
Unicycive Therapeutics (UNCY) United States $0.131B 0.00
Corbus Pharmaceuticals Holdings (CRBP) United States $0.129B 0.00
VAXART, INC (VXRT) United States $0.117B 3.00
Assertio Holdings (ASRT) United States $0.116B 0.00
Rafael Holdings (RFL) United States $0.111B 0.00
Vivani Medical (VANI) United States $0.111B 0.00
Allergy Therapeutics (AGYTF) United Kingdom $0.103B 0.00
Cassava Sciences (SAVA) United States $0.101B 0.00
Cumberland Pharmaceuticals (CPIX) United States $0.099B 0.00
PolyPid (PYPD) Israel $0.098B 0.00
HST Global (HSTC) United States $0.092B 0.00
ElectroCore (ECOR) United States $0.091B 0.00
Fractyl Health (GUTS) United States $0.090B 0.00
Nutriband (NTRB) United States $0.083B 0.00
Aldeyra Therapeutics (ALDX) United States $0.083B 0.00
Telomir Pharmaceuticals (TELO) United States $0.080B 0.00
Verrica Pharmaceuticals (VRCA) United States $0.079B 0.00
Acrivon Therapeutics (ACRV) United States $0.078B 0.00
Gain Therapeutics (GANX) United States $0.075B 0.00
PMV Pharmaceuticals (PMVP) United States $0.073B 0.00
Champions Oncology (CSBR) United States $0.066B 0.00
Talphera (TLPH) United States $0.062B 0.00
Nuo Therapeutics (AURX) $0.061B 0.00
Heron Therapeutics (HRTX) United States $0.060B 0.00
Dominari Holdings (DOMH) United States $0.053B 0.00
Veraxa Biotech AG (VRXA) United States $0.048B 0.00
SCYNEXIS (SCYX) United States $0.044B 0.00
Incannex Healthcare (IXHL) Australia $0.041B 0.00
FibroGen (FGEN) United States $0.039B 0.00
Lite Strategy (LITS) United States $0.037B 0.00
Mural Oncology (MURA) Ireland $0.035B 0.00
Karyopharm Therapeutics (KPTI) United States $0.035B 0.00
Context Therapeutics (CNTX) United States $0.033B 0.00
Optimi Health (OPTH) Canada $0.029B 0.00
Cosmos Health (COSM) United States $0.028B 0.00
TransCode Therapeutics (RNAZ) United States $0.027B 0.00
Plus Therapeutics (PSTV) United States $0.027B 0.00
TherapeuticsMD (TXMD) United States $0.025B 0.00
Universe Pharmaceuticals INC (UPC) China $0.022B 0.00
MARKER THERAPEUTICS, INC (MRKR) United States $0.020B 0.00
VYNE Therapeutics (VYNE) United States $0.019B 0.00
Lipocine (LPCN) United States $0.018B 0.00
Klotho Neurosciences (KLTO) United States $0.016B 0.00
Mannatech (MTEX) United States $0.016B 0.00
Enlivex (ENLV) Israel $0.015B 0.00
Citius Pharmaceuticals (CTXR) United States $0.015B 0.00
BioVie (BIVI) United States $0.015B 0.00
Iterum Therapeutics (ITRM) Ireland $0.015B 0.00
Vyome Holdings (HIND) United States $0.014B 0.00
Quoin Pharmaceuticals (QNRX) United States $0.014B 0.00
Scienture Holdings (SCNX) United States $0.014B 0.00
Tempest Therapeutics (TPST) United States $0.012B 0.00
Natural Alternatives (NAII) United States $0.012B 0.00
BioLineRx (BLRX) Israel $0.012B 0.00
Phio Pharmaceuticals (PHIO) United States $0.012B 0.00
Kiora Pharmaceuticals (KPRX) United States $0.012B 0.00
CASI Pharmaceuticals (CASI) China $0.010B 0.00
Xenetic Biosciences (XBIO) United States $0.010B 0.00
Mangoceuticals (MGRX) United States $0.009B 0.00
Wellgistics Health (WGRX) United States $0.009B 0.00
Traws Pharma (TRAW) United States $0.008B 0.00
Inotiv (NOTV) United States $0.008B 0.00
Biomerica (BMRA) United States $0.007B 0.00
Curanex Pharmaceuticals Inc (CURX) United States $0.007B 0.00
Ernexa Therapeutics (ERNA) United States $0.007B 0.00
Sonoma Pharmaceuticals (SNOA) United States $0.006B 0.00
XTL Biopharmaceuticals (XTLB) Israel $0.006B 0.00
Heatwurx (PCSA) United States $0.005B 0.00
Salarius Pharmaceuticals (SLRX) United States $0.005B 0.00
Galmed Pharmaceuticals (GLMD) Israel $0.005B 0.00
Liminatus Pharma (LIMN) United States $0.005B 0.00
Aptorum Group (APM) United Kingdom $0.004B 0.00
InMed Pharmaceuticals (INM) Canada $0.004B 0.00
Niki BioSolutions (NIKI) United Kingdom $0.004B 0.00
Nuvilex (PMCB) United States $0.004B 0.00
Addex Therapeutics (ADXN) Switzerland $0.004B 0.00
Galmed Pharmaceuticals (EOCN) Israel $0.004B 0.00
Alaunos Therapeutics (TCRT) United States $0.004B 0.00
Redhill Biopharma (RDHL) Israel $0.004B 0.00
XORTX Therapeutics (XRTX) Canada $0.003B 0.00
60 Degrees Pharmaceuticals (SXTP) United States $0.003B 0.00
Jupiter Neurosciences (JUNS) United States $0.003B 0.00
SciSparc (SPRC) Israel $0.003B 0.00
Vivos Therapeutics (VVOS) United States $0.002B 0.00
Shuttle Pharmaceuticals Holdings (SHPH) United States $0.002B 0.00
Jaguar Animal Health (JAGX) United States $0.001B 0.00
China SXT Pharmaceuticals (SXTC) China $0.001B 0.00
Clearmind Medicine (CMND) Canada $0.001B 0.00
PainReform (PRFX) Israel $0.001B 0.00
CDT Equity (CDT) United States $0.000B 0.00
Emisphere Technologies (EMIS) United States $0.000B 0.00
4D Pharma (LBPS) United Kingdom $0.000B 0.00
Patheon (PTHN) Netherlands $0.000B 0.00
RVL Pharmaceuticals (RVLP) United States $0.000B 0.00