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Ionis Pharmaceuticals Return on Tangible Equity 2011-2025 | IONS

Current and historical return on tangible equity values for Ionis Pharmaceuticals (IONS) over the last 10 years. Return on tangible equity can be defined as the amount of net income returned as a percentage of shareholders equity, after subtracting intangible assets, goodwill and preferred equity.
Ionis Pharmaceuticals Return On Tangible Equity Historical Data
Date TTM Net Income Tangible Equity Return on Tangible Equity
2025-09-30 $-0.26B $0.62B -44.25%
2025-06-30 $-0.27B $0.63B -45.29%
2025-03-31 $-0.46B $0.48B -91.86%
2024-12-31 $-0.45B $0.59B -100.06%
2024-09-30 $-0.36B $0.66B -88.94%
2024-06-30 $-0.37B $0.26B -115.60%
2024-03-31 $-0.38B $0.30B -107.64%
2023-12-31 $-0.37B $0.39B -90.29%
2023-09-30 $-0.41B $0.32B -90.52%
2023-06-30 $-0.31B $0.43B -60.01%
2023-03-31 $-0.33B $0.49B -59.07%
2022-12-31 $-0.27B $0.57B -44.57%
2022-09-30 $0.01B $0.57B 1.22%
2022-06-30 $-0.03B $0.60B -4.24%
2022-03-31 $0.00B $0.68B -0.48%
2021-12-31 $-0.03B $0.77B -4.52%
2021-09-30 $-0.61B $0.50B -100.50%
2021-06-30 $-0.55B $0.55B -62.89%
2021-03-31 $-0.50B $0.65B -43.88%
2020-12-31 $-0.45B $0.72B -32.94%
2020-09-30 $0.08B $1.58B 4.91%
2020-06-30 $0.13B $1.57B 8.20%
2020-03-31 $0.15B $1.54B 10.02%
2019-12-31 $0.28B $1.66B 18.71%
2019-09-30 $0.43B $1.47B 31.62%
2019-06-30 $0.40B $1.43B 33.36%
2019-03-31 $0.36B $1.36B 34.73%
2018-12-31 $0.27B $1.16B 34.94%
2018-09-30 $-0.05B $0.82B -8.46%
2018-06-30 $-0.05B $0.79B -10.02%
2018-03-31 $-0.01B $0.36B -3.13%
2017-12-31 $0.00B $0.34B 0.00%
2017-09-30 $0.06B $0.38B 26.51%
2017-06-30 $0.07B $0.19B 45.38%
2017-03-31 $0.01B $0.18B 9.38%
2016-12-31 $-0.06B $0.08B -57.28%
2016-09-30 $-0.18B $0.12B -139.39%
2016-06-30 $-0.23B $0.09B -143.22%
2016-03-31 $-0.13B $0.14B -65.05%
2015-12-31 $-0.09B $0.18B -37.37%
2015-09-30 $0.01B $0.23B 5.59%
2015-06-30 $0.02B $0.28B 8.35%
2015-03-31 $-0.03B $0.26B -8.55%
2014-12-31 $-0.04B $0.24B -12.31%
2014-09-30 $-0.09B $0.33B -27.17%
2014-06-30 $-0.09B $0.35B -25.64%
2014-03-31 $-0.09B $0.35B -24.61%
2013-12-31 $-0.06B $0.36B -19.00%
2013-09-30 $-0.04B $0.38B -14.76%
2013-06-30 $-0.05B $0.38B -24.85%
2013-03-31 $-0.04B $0.18B -29.00%
2012-12-31 $-0.07B $0.16B -47.40%
2012-09-30 $-0.08B $0.15B -60.92%
2012-06-30 $-0.07B $0.13B -51.52%
2012-03-31 $-0.09B $0.13B -57.89%
2011-12-31 $-0.09B $0.15B -49.28%
2011-09-30 $-0.08B $0.16B -41.58%
2011-06-30 $-0.06B $0.19B -30.99%
2011-03-31 $-0.07B $0.20B -32.49%
2010-12-31 $-0.06B $0.22B -26.26%
2010-09-30 $-0.06B $0.23B -25.99%
2010-06-30 $-0.06B $0.23B -24.76%
2010-03-31 $-0.04B $0.26B -15.63%
2009-12-31 $0.15B $0.27B 56.51%
2009-09-30 $0.16B $0.27B 69.10%
2009-06-30 $0.18B $0.27B 101.30%
2009-03-31 $0.17B $0.27B 158.18%
2008-12-31 $-0.02B $0.11B -38.30%
2008-09-30 $-0.02B $0.03B -205.13%
2008-06-30 $-0.13B $0.02B 1638.71%
2008-03-31 $-0.13B $0.02B 1218.18%
2007-12-31 $-0.14B $-0.04B 1311.63%
2007-09-30 $-0.14B $-0.04B -2600.00%
2007-06-30 $-0.05B $0.01B -909.09%
2007-03-31 $-0.04B $0.02B 713.04%
2006-12-31 $-0.05B $0.03B 195.65%
2006-09-30 $-0.04B $-0.04B 96.30%
2006-06-30 $-0.04B $-0.04B 101.82%
2006-03-31 $-0.06B $-0.05B 80.27%
2005-12-31 $-0.07B $-0.04B 73.37%
2005-09-30 $-0.12B $-0.04B 103.58%
2005-06-30 $-0.14B $-0.17B 111.68%
2005-03-31 $-0.15B $-0.15B 156.38%
2004-12-31 $-0.14B $-0.12B 247.62%
2004-09-30 $-0.11B $-0.07B 453.06%
2004-06-30 $-0.10B $-0.04B -2666.67%
2004-03-31 $-0.10B $0.00B -328.81%
2003-12-31 $-0.10B $0.02B -184.47%
2003-09-30 $-0.09B $0.04B -114.86%
2003-06-30 $-0.08B $0.06B -86.86%
2003-03-31 $-0.08B $0.08B -70.69%
2002-12-31 $-0.07B $0.11B -56.59%
2002-09-30 $-0.07B $0.12B -50.00%
2002-06-30 $-0.07B $0.14B -50.65%
2002-03-31 $-0.07B $0.15B -69.83%
2001-12-31 $-0.08B $0.17B -107.53%
2001-09-30 $-0.07B $0.07B -188.54%
2001-06-30 $-0.07B $0.00B -194.20%
2001-03-31 $-0.06B $0.03B -114.01%
2000-12-31 $-0.06B $0.05B -103.77%
2000-09-30 $-0.06B $0.05B -154.67%
2000-06-30 $-0.06B $0.07B -336.84%
2000-03-31 $-0.07B $0.04B -26400.00%
1999-12-31 $-0.06B $-0.01B 400.00%
1999-09-30 $-0.06B $-0.02B 437.04%
1999-06-30 $-0.05B $-0.01B 872.73%
1999-03-31 $-0.05B $-0.03B 4500.00%
1998-12-31 $-0.04B $0.00B -382.61%
1998-09-30 $-0.04B $0.01B -197.40%
1998-06-30 $-0.04B $0.01B -157.58%
1998-03-31 $-0.03B $0.03B -112.40%
1997-12-31 $-0.03B $0.03B -87.94%
1997-09-30 $-0.03B $0.03B -67.47%
1997-06-30 $-0.03B $0.04B -68.82%
1997-03-31 $-0.03B $0.05B -56.60%
1996-12-31 $-0.03B $0.05B -62.28%
1996-09-30 $-0.02B $0.05B -49.46%
1996-06-30 $-0.02B $0.06B -53.04%
1996-03-31 $-0.02B -60.13%
1995-12-31 $-0.02B $0.07B -50.79%
1995-09-30 $-0.03B $0.05B -62.50%
1995-06-30 $-0.02B $0.03B -56.44%
1995-03-31 $-0.02B $0.04B -47.06%
1994-12-31 $-0.02B $0.04B -33.64%
1994-09-30 $-0.02B $0.05B -29.82%
1994-06-30 $-0.02B $0.06B -30.91%
1994-03-31 $-0.02B $0.06B -32.23%
1993-12-31 $-0.02B $0.06B -39.80%
1993-09-30 $-0.02B $0.04B -43.48%
1993-06-30 $-0.02B $0.05B -43.24%
1993-03-31 $-0.02B $0.05B -40.64%
1992-12-31 $-0.02B $0.04B -40.43%
1992-06-30 $-0.01B $0.05B -22.68%
1992-03-31 $-0.01B $0.05B -20.34%
Sector Industry Market Cap Revenue
Medical Medical - Drug Manufacturing $12.002B $0.705B
Ionis Pharmaceuticals discovers/develops RNA-targeted therapeutics using its proprietary antisense oligonucleotide technology. Its antisense medicines have been developed/are being developed to treat neurological, cardiovascular and specialty rare diseases.
Stock Name Country Market Cap PE Ratio
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Zoetis (ZTS) United States $52.689B 18.86
Takeda Pharmaceutical (TAK) Japan $43.402B 8.86
Daiichi Sankyo, - (DSNKY) Japan $41.941B 20.89
BeOne Medicines - (ONC) Switzerland $36.448B 193.23
Sandoz Group AG (SDZNY) Switzerland $29.586B 0.00
United Therapeutics (UTHR) United States $19.548B 17.20
Merck (MKKGY) Germany $16.433B 10.69
Neurocrine Biosciences (NBIX) United States $15.434B 37.03
Shionogi (SGIOY) Japan $14.445B 13.27
Summit Therapeutics (SMMT) United States $14.228B 0.00
IPSEN (IPSEY) France $11.841B 0.00
Madrigal Pharmaceuticals (MDGL) United States $11.096B 0.00
Orion OYJ (ORINY) Finland $8.793B 25.12
Eisai (ESAIY) $8.166B 0.00
Corcept Therapeutics (CORT) United States $7.685B 83.02
Stevanato Group S.p.A (STVN) Italy $7.392B 41.37
Grifols, S.A (GRFS) Spain $5.748B 0.00
Ono Pharmaceutical (OPHLF) Japan $5.730B 17.43
Hikma Pharmaceuticals Plc (HKMPF) United Kingdom $4.549B 0.00
NewAmsterdam Pharma (NAMS) Netherlands $4.173B 0.00
Crinetics Pharmaceuticals (CRNX) United States $4.096B 0.00
AMNEAL PHARMACEUTICALS, INC (AMRX) United States $3.662B 17.40
Centessa Pharmaceuticals (CNTA) United Kingdom $3.058B 0.00
Hypermarcas (HYPMY) Brazil $2.899B 21.80
Dyne Therapeutics (DYN) United States $2.600B 0.00
Catalyst Pharmaceuticals (CPRX) United States $2.580B 8.23
Soleno Therapeutics (SLNO) United States $2.339B 0.00
Ocular Therapeutix (OCUL) United States $2.265B 0.00
Aurinia Pharmaceuticals Inc (AUPH) Canada $1.839B 21.80
Avadel Pharmaceuticals (AVDL) Ireland $1.817B 0.00
Guardian Pharmacy Services (GRDN) United States $1.804B 0.00
BioCryst Pharmaceuticals (BCRX) United States $1.480B 87.88
Ardelyx (ARDX) United States $1.373B 0.00
Collegium Pharmaceutical (COLL) United States $1.281B 6.36
Harrow (HROW) United States $1.274B 0.00
Xeris Biopharma Holdings (XERS) United States $1.245B 0.00
Oruka Therapeutics (ORKA) United States $1.175B 0.00
Evotec AG (EVO) Germany $1.174B 0.00
Relay Therapeutics (RLAY) United States $1.126B 0.00
Amylyx Pharmaceuticals (AMLX) United States $1.111B 0.00
Enliven Therapeutics (ELVN) United States $1.084B 0.00
Nektar Therapeutics (NKTR) United States $1.048B 0.00
Xencor (XNCR) United States $1.000B 0.00
Cronos Group (CRON) Canada $0.946B 0.00
ProKidney (PROK) United States $0.827B 0.00
ARS Pharmaceuticals (SPRY) United States $0.810B 0.00
Theravance Biopharma (TBPH) United States $0.749B 61.96
Aquestive Therapeutics (AQST) United States $0.748B 0.00
Savara (SVRA) United States $0.688B 0.00
Rigel Pharmaceuticals (RIGL) United States $0.656B 5.85
Elite Pharmaceuticals (ELTP) United States $0.645B 0.00
Bioventus (BVS) United States $0.618B 12.68
Siga Technologies (SIGA) United States $0.585B 8.01
KalVista Pharmaceuticals (KALV) United States $0.550B 0.00
Akebia Therapeutics (AKBA) United States $0.533B 0.00
Zevra Therapeutics (ZVRA) United States $0.512B 0.00
4D Molecular Therapeutics (FDMT) United States $0.510B 0.00
Esperion Therapeutics (ESPR) United States $0.504B 0.00
Organogenesis (ORGO) United States $0.493B 0.00
Lexeo Therapeutics (LXEO) United States $0.455B 0.00
Galectin Therapeutics (GALT) United States $0.360B 0.00
USANA Health Sciences (USNA) United States $0.350B 9.78
Altimmune (ALT) United States $0.348B 0.00
Lyell Immunopharma (LYEL) United States $0.344B 0.00
Ironwood Pharmaceuticals (IRWD) United States $0.333B 51.25
Korro Bio (KRRO) United States $0.306B 0.00
Aldeyra Therapeutics (ALDX) United States $0.289B 0.00
Larimar Therapeutics (LRMR) United States $0.287B 0.00
Pyxis Oncology (PYXS) United States $0.252B 0.00
Aclaris Therapeutics (ACRS) United States $0.246B 0.00
Achieve Life Sciences (ACHV) Canada $0.242B 0.00
Nature's Sunshine Products (NATR) United States $0.242B 14.30
Journey Medical (DERM) United States $0.242B 0.00
AleAnna (ANNA) United States $0.219B 0.00
Avalo Therapeutics (AVTX) United States $0.203B 0.00
Heron Therapeutics (HRTX) United States $0.202B 0.00
MediWound (MDWD) Israel $0.200B 0.00
OmniAb (OABI) United States $0.199B 0.00
Profound Medical (PROF) Canada $0.177B 0.00
Innate Pharma SA (IPHYF) France $0.168B 0.00
China SXT Pharmaceuticals (SXTC) China $0.166B 0.00
Protara Therapeutics (TARA) United States $0.166B 0.00
Tonix Pharmaceuticals Holding (TNXP) United States $0.153B 0.00
Cassava Sciences (SAVA) United States $0.143B 0.00
Corbus Pharmaceuticals Holdings (CRBP) United States $0.128B 0.00
Incannex Healthcare (IXHL) Australia $0.127B 0.00
Inhibikase Therapeutics (IKT) United States $0.111B 0.00
Surrozen (SRZN) United States $0.107B 0.00
Cardiol Therapeutics (CRDL) Canada $0.101B 0.00
Context Therapeutics (CNTX) United States $0.098B 0.00
Champions Oncology (CSBR) United States $0.095B 34.40
Vivani Medical (VANI) United States $0.093B 0.00
Avita Medical (RCEL) United States $0.091B 0.00
VAXART, INC (VXRT) United States $0.087B 0.00
Relmada Therapeutics (RLMD) United States $0.087B 0.00
Metagenomi (MGX) United States $0.083B 0.00
Unicycive Therapeutics (UNCY) United States $0.079B 0.00
Prelude Therapeutics (PRLD) United States $0.076B 0.00
Dominari Holdings (DOMH) United States $0.074B 0.00
Assertio Holdings (ASRT) United States $0.073B 0.00
Procaps Group, S.A (PROCF) Luxembourg $0.071B 0.00
Gain Therapeutics (GANX) United States $0.068B 0.00
Nutriband (NTRB) United States $0.067B 0.00
PMV Pharmaceuticals (PMVP) United States $0.066B 0.00
Lite Strategy (LITS) United States $0.066B 0.00
Acrivon Therapeutics (ACRV) United States $0.063B 0.00
Wellgistics Health (WGRX) United States $0.062B 0.00
PolyPid (PYPD) Israel $0.060B 0.00
BioNxt Solutions (BNXTF) Canada $0.060B 0.00
Fractyl Health (GUTS) United States $0.055B 0.00
Talphera (TLPH) United States $0.054B 0.00
NRx Pharmaceuticals (NRXP) United States $0.053B 0.00
Plus Therapeutics (PSTV) United States $0.051B 0.00
Jupiter Neurosciences (JUNS) United States $0.047B 0.00
ElectroCore (ECOR) United States $0.047B 0.00
Century Therapeutics (IPSC) United States $0.047B 0.00
Rafael Holdings (RFL) United States $0.046B 0.00
Karyopharm Therapeutics (KPTI) United States $0.045B 0.00
FibroGen (FGEN) United States $0.044B 0.00
Telomir Pharmaceuticals (TELO) United States $0.044B 0.00
Tempest Therapeutics (TPST) United States $0.042B 0.00
Inotiv (NOTV) United States $0.040B 0.00
Mural Oncology (MURA) Ireland $0.036B 0.00
Reviva Pharmaceuticals Holdings (RVPH) United States $0.035B 0.00
Liminatus Pharma (LIMN) United States $0.035B 0.00
Klotho Neurosciences (KLTO) United States $0.034B 0.00
Verrica Pharmaceuticals (VRCA) United States $0.034B 0.00
Cumberland Pharmaceuticals (CPIX) United States $0.033B 27.38
Iterum Therapeutics (ITRM) Ireland $0.028B 0.00
Scienture Holdings (SCNX) United States $0.026B 0.00
SCYNEXIS (SCYX) United States $0.025B 0.00
Enlivex Therapeutics (ENLV) Israel $0.025B 0.00
Citius Pharmaceuticals (CTXR) United States $0.021B 0.00
Cosmos Health (COSM) United States $0.021B 0.00
Vyome Holdings (HIND) United States $0.021B 0.00
Mangoceuticals (MGRX) United States $0.019B 0.00
Natural Alternatives (NAII) United States $0.018B 0.00
Vivos Therapeutics (VVOS) United States $0.017B 0.00
Mannatech (MTEX) United States $0.017B 0.00
CASI Pharmaceuticals (CASI) China $0.016B 0.00
Heatwurx (PCSA) United States $0.016B 0.00
TherapeuticsMD (TXMD) United States $0.015B 0.00
BioLineRx (BLRX) Israel $0.014B 0.00
Traws Pharma (TRAW) United States $0.014B 0.02
Lipocine (LPCN) United States $0.014B 0.00
Ainos (AIMD) United States $0.014B 0.00
Ernexa Therapeutics (ERNA) United States $0.013B 0.00
ProPhase Labs (PRPH) United States $0.012B 0.00
MARKER THERAPEUTICS, INC (MRKR) United States $0.011B 0.00
BioVie (BIVI) United States $0.011B 0.00
Addex Therapeutics (ADXN) Switzerland $0.009B 0.00
VYNE Therapeutics (VYNE) United States $0.009B 0.00
Phio Pharmaceuticals (PHIO) United States $0.008B 0.00
Lyra Therapeutics (LYRA) United States $0.008B 0.00
Kiora Pharmaceuticals (KPRX) United States $0.008B 0.00
TransCode Therapeutics (RNAZ) United States $0.008B 0.00
Biomerica (BMRA) United States $0.008B 0.00
Aptorum Group (APM) United Kingdom $0.007B 0.00
Sonoma Pharmaceuticals (SNOA) United States $0.006B 0.00
Nuvilex (PMCB) United States $0.006B 0.00
Alaunos Therapeutics (TCRT) United States $0.006B 0.00
XTL Biopharmaceuticals (XTLB) Israel $0.005B 0.00
60 Degrees Pharmaceuticals (SXTP) United States $0.005B 0.00
Quoin Pharmaceuticals (QNRX) United States $0.005B 0.00
InMed Pharmaceuticals (INM) Canada $0.005B 0.00
Qualigen Therapeutics (QLGN) United States $0.004B 0.00
Xenetic Biosciences (XBIO) United States $0.004B 0.00
Clearmind Medicine (CMND) Canada $0.004B 0.00
Redhill Biopharma (RDHL) Israel $0.004B 0.00
Jaguar Animal Health (JAGX) United States $0.004B 0.00
CDT Equity (CDT) United States $0.003B 0.00
XORTX Therapeutics (XRTX) Canada $0.003B 0.00
Indaptus Therapeutics (INDP) United States $0.003B 0.00
Shuttle Pharmaceuticals Holdings (SHPH) United States $0.003B 0.00
Universe Pharmaceuticals INC (UPC) China $0.002B 0.00
PainReform (PRFX) Israel $0.002B 0.00
Galmed Pharmaceuticals (GLMD) Israel $0.002B 0.00
NewcelX (NCEL) Switzerland $0.001B 0.00
Salarius Pharmaceuticals (SLRX) United States $0.001B 0.00
SciSparc (SPRC) Israel $0.001B 0.00
Aditxt (ADTX) United States $0.000B 0.00
Curanex Pharmaceuticals Inc (CURX) United States $0.000B 0.00
Emisphere Technologies (EMIS) United States $0.000B 0.00
Indivior (INDV) United States $0.000B 16.26
4D Pharma (LBPS) United Kingdom $0.000B 0.00
Minerva Neurosciences (NERV) United States $0.000B 0.00
Patheon (PTHN) Netherlands $0.000B 0.00
RVL Pharmaceuticals (RVLP) United States $0.000B 0.00
Silence Therapeutics (SLN) United Kingdom $0.000B 0.00