Ono Pharmaceutical EBITDA Margin 2012-2025 | OPHLF

Current and historical EBITDA (Earnings Before Interest, Taxes, Depreciation and Amortization) margin for Ono Pharmaceutical (OPHLF) over the last 10 years. The current EBITDA margin for Ono Pharmaceutical as of September 30, 2025 is .

Ono Pharmaceutical EBITDA Margin Historical Data
Date	TTM Revenue	TTM EBITDA	EBITDA Margin
2025-06-30	$3.33B	$1.10B	33.08%
2024-06-30	$3.25B	$1.20B	36.85%
2023-06-30	$3.19B	$1.26B	39.47%
2022-06-30	$2.99B	$1.14B	38.03%
2021-06-30	$2.82B	$1.00B	35.39%
2020-06-30	$2.57B	$0.84B	32.50%
2019-06-30	$2.45B	$0.73B	29.98%
2018-06-30	$2.27B	$0.05B	2.38%
2017-06-30	$1.96B	$0.21B	10.77%
2016-06-30	$1.71B	$0.38B	21.94%
2016-03-31	$1.43B	$0.30B	20.89%
2015-12-31	$1.18B	$1.02B	86.64%
2015-09-30	$1.15B	$0.99B	86.36%
2015-06-30	$1.11B	$0.94B	84.59%
2015-03-31	$1.13B	$0.87B	77.03%
2014-12-31	$1.22B	$0.95B	77.68%
2014-09-30	$1.25B	$0.97B	78.07%
2014-06-30	$1.34B	$1.06B	79.58%
2014-03-31	$1.41B	$1.10B	78.58%
2013-12-31	$1.33B	$1.03B	77.39%
2013-09-30	$1.37B	$1.07B	77.98%
2013-06-30	$1.46B	$1.16B	79.37%
2013-03-31	$1.55B	$1.23B	79.31%
2012-12-31	$1.61B	$1.29B	80.06%
2012-09-30	$1.77B	$1.45B	81.88%
2012-06-30	$1.78B	$1.46B	82.01%
2011-12-31	$1.38B	$1.38B	100.00%
2011-06-30	$1.22B	$1.22B	100.00%
2010-06-30	$1.41B	$1.41B	100.00%
2009-06-30	$1.35B	$1.35B	100.00%
2008-06-30	$1.32B	$1.32B	100.00%

Sector	Industry	Market Cap	Revenue
Medical	Medical - Drug Manufacturing	$6.967B	$3.197B
Ono Pharmaceuticals produces, purchases and sells pharmaceuticals and diagnostic reagents focusing primarily on prescription pharmaceuticals.

Stock Name	Country	Market Cap	PE Ratio
Chugai Pharmaceutical (CHGCY)	Japan	$87.081B	33.08
Zoetis (ZTS)	United States	$54.822B	19.62
Takeda Pharmaceutical (TAK)	Japan	$50.721B	10.35
Daiichi Sankyo, - (DSNKY)	Japan	$37.925B	18.89
BeOne Medicines - (ONC)	Switzerland	$37.155B	196.98
Sandoz Group AG (SDZNY)	Switzerland	$34.654B	0.00
United Therapeutics (UTHR)	United States	$20.325B	17.89
Merck (MKKGY)	Germany	$19.522B	12.04
Shionogi (SGIOY)	Japan	$16.214B	14.89
Neurocrine Biosciences (NBIX)	United States	$13.697B	32.86
Summit Therapeutics (SMMT)	United States	$13.395B	0.00
IPSEN (IPSEY)	France	$13.337B	0.00
Ionis Pharmaceuticals (IONS)	United States	$13.248B	0.00
Madrigal Pharmaceuticals (MDGL)	United States	$11.311B	0.00
Orion OYJ (ORINY)	Finland	$10.204B	29.15
Eisai (ESAIY)		$8.236B	0.00
Grifols, S.A (GRFS)	Spain	$6.264B	0.00
Stevanato Group S.p.A (STVN)	Italy	$5.802B	32.47
Crinetics Pharmaceuticals (CRNX)	United States	$5.214B	0.00
Hikma Pharmaceuticals Plc (HKMPF)	United Kingdom	$4.547B	0.00
Corcept Therapeutics (CORT)	United States	$4.344B	46.93
AMNEAL PHARMACEUTICALS, INC (AMRX)	United States	$4.269B	20.27
Indivior (INDV)	United States	$4.193B	17.11
NewAmsterdam Pharma (NAMS)	Netherlands	$3.947B	0.00
Centessa Pharmaceuticals (CNTA)	United Kingdom	$3.313B	0.00
Hypermarcas (HYPMY)	Brazil	$3.192B	21.91
Catalyst Pharmaceuticals (CPRX)	United States	$3.005B	9.59
Dyne Therapeutics (DYN)	United States	$2.582B	0.00
Ocular Therapeutix (OCUL)	United States	$2.369B	0.00
Soleno Therapeutics (SLNO)	United States	$2.350B	0.00
Avadel Pharmaceuticals (AVDL)	Ireland	$2.103B	0.00
Aurinia Pharmaceuticals Inc (AUPH)	Canada	$1.959B	23.22
Ardelyx (ARDX)	United States	$1.927B	0.00
Guardian Pharmacy Services (GRDN)	United States	$1.924B	37.06
Amylyx Pharmaceuticals (AMLX)	United States	$1.782B	0.00
Oruka Therapeutics (ORKA)	United States	$1.720B	0.00
Harrow (HROW)	United States	$1.679B	103.00
Enliven Therapeutics (ELVN)	United States	$1.604B	0.00
Collegium Pharmaceutical (COLL)	United States	$1.489B	7.37
BioCryst Pharmaceuticals (BCRX)	United States	$1.422B	84.38
Relay Therapeutics (RLAY)	United States	$1.317B	0.00
Savara (SVRA)	United States	$1.314B	0.00
Evotec AG (EVO)	Germany	$1.275B	0.00
Xeris Biopharma Holdings (XERS)	United States	$1.263B	0.00
Aktis Oncology (AKTS)	United States	$1.135B	0.00
Theravance Biopharma (TBPH)	United States	$1.051B	44.13
ARS Pharmaceuticals (SPRY)	United States	$1.045B	0.00
Cronos Group (CRON)	Canada	$1.023B	0.00
Xencor (XNCR)	United States	$0.936B	0.00
Ironwood Pharmaceuticals (IRWD)	United States	$0.877B	20.73
KalVista Pharmaceuticals (KALV)	United States	$0.836B	0.00
Esperion Therapeutics (ESPR)	United States	$0.758B	0.00
Nektar Therapeutics (NKTR)	United States	$0.743B	0.00
Rigel Pharmaceuticals (RIGL)	United States	$0.688B	6.15
Bioventus (BVS)	United States	$0.675B	13.81
ProKidney (PROK)	United States	$0.656B	0.00
Altimmune (ALT)	United States	$0.561B	0.00
Lexeo Therapeutics (LXEO)	United States	$0.561B	0.00
Lyell Immunopharma (LYEL)	United States	$0.549B	0.00
Zevra Therapeutics (ZVRA)	United States	$0.511B	0.00
Organogenesis (ORGO)	United States	$0.508B	0.00
Elite Pharmaceuticals (ELTP)	United States	$0.494B	0.00
Aclaris Therapeutics (ACRS)	United States	$0.491B	0.00
Siga Technologies (SIGA)	United States	$0.482B	6.60
4D Molecular Therapeutics (FDMT)	United States	$0.462B	0.00
Nature's Sunshine Products (NATR)	United States	$0.429B	25.56
USANA Health Sciences (USNA)	United States	$0.412B	11.48
Aquestive Therapeutics (AQST)	United States	$0.397B	0.00
Cybin (HELP)	Canada	$0.385B	0.00
Akebia Therapeutics (AKBA)	United States	$0.382B	0.00
Aldeyra Therapeutics (ALDX)	United States	$0.314B	0.00
Protara Therapeutics (TARA)	United States	$0.305B	0.00
Avalo Therapeutics (AVTX)	United States	$0.301B	0.00
OmniAb (OABI)	United States	$0.298B	0.00
Achieve Life Sciences (ACHV)	Canada	$0.294B	0.00
Relmada Therapeutics (RLMD)	United States	$0.290B	0.00
Larimar Therapeutics (LRMR)	United States	$0.286B	0.00
Fractyl Health (GUTS)	United States	$0.284B	0.00
Profound Medical (PROF)	Canada	$0.281B	0.00
Silence Therapeutics (SLN)	United Kingdom	$0.275B	0.00
Heron Therapeutics (HRTX)	United States	$0.266B	0.00
Journey Medical (DERM)	United States	$0.251B	0.00
Enlivex Therapeutics (ENLV)	Israel	$0.249B	0.00
Tonix Pharmaceuticals Holding (TNXP)	United States	$0.231B	0.00
Galectin Therapeutics (GALT)	United States	$0.228B	0.00
MediWound (MDWD)	Israel	$0.225B	0.00
Century Therapeutics (IPSC)	United States	$0.202B	0.00
AleAnna (ANNA)	United States	$0.187B	0.00
Innate Pharma SA (IPHYF)	France	$0.181B	0.00
Surrozen (SRZN)	United States	$0.171B	0.00
Minerva Neurosciences (NERV)	United States	$0.169B	0.00
Context Therapeutics (CNTX)	United States	$0.164B	0.00
Procaps Group, S.A (PROCF)	Luxembourg	$0.161B	0.00
VAXART, INC (VXRT)	United States	$0.159B	0.00
Corbus Pharmaceuticals Holdings (CRBP)	United States	$0.156B	0.00
Unicycive Therapeutics (UNCY)	United States	$0.153B	0.00
Prelude Therapeutics (PRLD)	United States	$0.139B	0.00
Inhibikase Therapeutics (IKT)	United States	$0.135B	0.00
Avita Medical (RCEL)	United States	$0.126B	0.00
Incannex Healthcare (IXHL)	Australia	$0.124B	0.00
Verrica Pharmaceuticals (VRCA)	United States	$0.124B	0.00
Karyopharm Therapeutics (KPTI)	United States	$0.122B	0.00
Cassava Sciences (SAVA)	United States	$0.112B	0.00
Vivani Medical (VANI)	United States	$0.107B	0.00
Pyxis Oncology (PYXS)	United States	$0.106B	0.00
Cardiol Therapeutics (CRDL)	Canada	$0.104B	0.00
Korro Bio (KRRO)	United States	$0.099B	0.00
Champions Oncology (CSBR)	United States	$0.096B	40.76
Gain Therapeutics (GANX)	United States	$0.080B	0.00
PolyPid (PYPD)	Israel	$0.076B	0.00
Assertio Holdings (ASRT)	United States	$0.075B	0.00
NRx Pharmaceuticals (NRXP)	United States	$0.069B	0.00
Dominari Holdings (DOMH)	United States	$0.068B	0.00
Metagenomi Therapeutics (MGX)	United States	$0.066B	0.00
Acrivon Therapeutics (ACRV)	United States	$0.064B	0.00
Arch Biopartners (ACHFF)	Canada	$0.062B	0.00
Rafael Holdings (RFL)	United States	$0.062B	0.00
PMV Pharmaceuticals (PMVP)	United States	$0.061B	0.00
Cumberland Pharmaceuticals (CPIX)	United States	$0.060B	50.50
Lipocine (LPCN)	United States	$0.058B	0.00
ElectroCore (ECOR)	United States	$0.056B	0.00
Nutriband (NTRB)	United States	$0.055B	0.00
Lite Strategy (LITS)	United States	$0.049B	0.00
Talphera (TLPH)	United States	$0.047B	0.00
Telomir Pharmaceuticals (TELO)	United States	$0.046B	0.00
Plus Therapeutics (PSTV)	United States	$0.040B	0.00
FibroGen (FGEN)	United States	$0.039B	0.00
Reviva Pharmaceuticals Holdings (RVPH)	United States	$0.039B	0.00
Wellgistics Health (WGRX)	United States	$0.036B	0.00
Mural Oncology (MURA)	Ireland	$0.035B	0.00
MARKER THERAPEUTICS, INC (MRKR)	United States	$0.034B	0.00
Jupiter Neurosciences (JUNS)	United States	$0.032B	0.00
SCYNEXIS (SCYX)	United States	$0.032B	0.00
TherapeuticsMD (TXMD)	United States	$0.030B	0.00
Natural Alternatives (NAII)	United States	$0.027B	0.00
Klotho Neurosciences (KLTO)	United States	$0.025B	0.00
Liminatus Pharma (LIMN)	United States	$0.021B	0.00
Scienture Holdings (SCNX)	United States	$0.021B	0.00
Traws Pharma (TRAW)	United States	$0.020B	0.03
Inotiv (NOTV)	United States	$0.020B	0.00
VYNE Therapeutics (VYNE)	United States	$0.019B	0.00
Cosmos Health (COSM)	United States	$0.019B	0.00
Iterum Therapeutics (ITRM)	Ireland	$0.019B	0.00
Citius Pharmaceuticals (CTXR)	United States	$0.018B	0.00
Vivos Therapeutics (VVOS)	United States	$0.017B	0.00
Vyome Holdings (HIND)	United States	$0.016B	0.00
Tempest Therapeutics (TPST)	United States	$0.015B	0.00
Mannatech (MTEX)	United States	$0.014B	0.00
BioLineRx (BLRX)	Israel	$0.013B	0.00
CASI Pharmaceuticals (CASI)	China	$0.012B	0.00
Phio Pharmaceuticals (PHIO)	United States	$0.012B	0.00
China SXT Pharmaceuticals (SXTC)	China	$0.011B	0.00
Curanex Pharmaceuticals Inc (CURX)	United States	$0.010B	0.00
Addex Therapeutics (ADXN)	Switzerland	$0.010B	0.00
Ernexa Therapeutics (ERNA)	United States	$0.010B	0.00
BioVie (BIVI)	United States	$0.009B	0.00
XTL Biopharmaceuticals (XTLB)	Israel	$0.009B	0.00
Nuvilex (PMCB)	United States	$0.009B	0.00
Ainos (AIMD)	United States	$0.009B	0.00
Mangoceuticals (MGRX)	United States	$0.009B	0.00
TransCode Therapeutics (RNAZ)	United States	$0.009B	0.00
Kiora Pharmaceuticals (KPRX)	United States	$0.008B	0.00
Quoin Pharmaceuticals (QNRX)	United States	$0.008B	0.00
Biomerica (BMRA)	United States	$0.008B	0.00
Heatwurx (PCSA)	United States	$0.007B	0.00
Redhill Biopharma (RDHL)	Israel	$0.007B	0.00
Alaunos Therapeutics (TCRT)	United States	$0.007B	0.00
Indaptus Therapeutics (INDP)	United States	$0.006B	0.00
Xenetic Biosciences (XBIO)	United States	$0.006B	0.00
Aptorum Group (APM)	United Kingdom	$0.006B	0.00
Sonoma Pharmaceuticals (SNOA)	United States	$0.006B	0.00
60 Degrees Pharmaceuticals (SXTP)	United States	$0.005B	0.00
Salarius Pharmaceuticals (SLRX)	United States	$0.005B	0.00
Clearmind Medicine (CMND)	Canada	$0.004B	0.00
Lyra Therapeutics (LYRA)	United States	$0.004B	0.00
XORTX Therapeutics (XRTX)	Canada	$0.004B	0.00
Shuttle Pharmaceuticals Holdings (SHPH)	United States	$0.004B	0.00
InMed Pharmaceuticals (INM)	Canada	$0.003B	0.00
Jaguar Animal Health (JAGX)	United States	$0.003B	0.00
Universe Pharmaceuticals INC (UPC)	China	$0.002B	0.00
CDT Equity (CDT)	United States	$0.002B	0.00
PainReform (PRFX)	Israel	$0.002B	0.00
Galmed Pharmaceuticals (GLMD)	Israel	$0.001B	0.00
Aditxt (ADTX)	United States	$0.001B	0.00
SciSparc (SPRC)	Israel	$0.001B	0.00
Emisphere Technologies (EMIS)	United States	$0.000B	0.00
4D Pharma (LBPS)	United Kingdom	$0.000B	0.00
Patheon (PTHN)	Netherlands	$0.000B	0.00
RVL Pharmaceuticals (RVLP)	United States	$0.000B	0.00