Madrigal Pharmaceuticals Pre-Tax Profit Margin 2012-2025 | MDGL

Current and historical pre-tax profit margin for Madrigal Pharmaceuticals (MDGL) from 2012 to 2025. Pre-tax profit margin can be defined as earnings before taxes as a portion of total revenue. Madrigal Pharmaceuticals pre-tax profit margin for the three months ending September 30, 2025 was .

Madrigal Pharmaceuticals Pre-Tax Profit Margin Historical Data
Date	TTM Revenue	TTM Pre-Tax Income	Pre-Tax Margin
2025-09-30	$0.74B	$-0.29B	-38.92%
2025-06-30	$0.52B	$-0.28B	-54.56%
2025-03-31	$0.32B	$-0.39B	-123.34%
2012-03-31	$0.01B	$-0.05B	-866.67%
2011-12-31	$0.01B	$-0.05B	-685.71%
2011-09-30	$0.01B	$-0.05B	-575.00%
2011-06-30	$0.01B	$-0.04B	-477.78%
2011-03-31	$0.01B	$-0.04B	-354.55%
2010-12-31	$0.01B	$-0.04B	-264.29%
2010-09-30	$0.02B	$-0.04B	-233.33%
2010-06-30	$0.14B	$0.09B	65.49%
2010-03-31	$0.14B	$0.09B	65.28%
2009-12-31	$0.15B	$0.08B	55.17%
2009-09-30	$0.14B	$0.06B	43.26%
2009-06-30	$0.01B	$-0.08B	-691.67%
2009-03-31	$0.01B	$-0.10B	-1633.33%
2008-12-31	$0.00B	$-0.09B	-4650.00%

Sector	Industry	Market Cap	Revenue
Medical	Medical - Drug Manufacturing	$11.595B	$0.180B
Madrigal Pharmaceuticals, Inc. is engaged in developing small-molecule drugs addressing cardiovascular and metabolic diseases. Its products pipeline include MGL-3196, an orally administered liver-directed thyroid hormone receptor-? agonist that is used for the treatment of NASH, dyslipidemia/hypercholesterolemia and high triglycerides; and MGL-3745, a thyroid hormone receptor-? agonist which are in pre-clinical trial stage. Madrigal Pharmaceuticals Inc., formerly known as Synta Pharmaceuticals Corp., is based in Fort Washington, Pennsylvania.

Stock Name	Country	Market Cap	PE Ratio
Chugai Pharmaceutical (CHGCY)	Japan	$89.220B	33.89
Zoetis (ZTS)	United States	$55.228B	19.77
Takeda Pharmaceutical (TAK)	Japan	$51.739B	10.56
Daiichi Sankyo, - (DSNKY)	Japan	$43.684B	21.75
BeOne Medicines - (ONC)	Switzerland	$36.626B	194.18
Sandoz Group AG (SDZNY)	Switzerland	$33.097B	0.00
United Therapeutics (UTHR)	United States	$20.770B	18.28
Merck (MKKGY)	Germany	$19.845B	12.23
Shionogi (SGIOY)	Japan	$15.823B	14.53
Neurocrine Biosciences (NBIX)	United States	$13.227B	31.74
Ionis Pharmaceuticals (IONS)	United States	$13.227B	0.00
Summit Therapeutics (SMMT)	United States	$13.140B	0.00
IPSEN (IPSEY)	France	$12.596B	0.00
Orion OYJ (ORINY)	Finland	$11.045B	31.56
Eisai (ESAIY)		$8.889B	0.00
Ono Pharmaceutical (OPHLF)	Japan	$6.576B	20.00
Grifols, S.A (GRFS)	Spain	$6.284B	0.00
Stevanato Group S.p.A (STVN)	Italy	$6.278B	35.14
Crinetics Pharmaceuticals (CRNX)	United States	$5.252B	0.00
Hikma Pharmaceuticals Plc (HKMPF)	United Kingdom	$4.613B	0.00
Indivior (INDV)	United States	$4.321B	17.63
AMNEAL PHARMACEUTICALS, INC (AMRX)	United States	$4.080B	19.37
Corcept Therapeutics (CORT)	United States	$3.930B	42.46
NewAmsterdam Pharma (NAMS)	Netherlands	$3.707B	0.00
Centessa Pharmaceuticals (CNTA)	United Kingdom	$2.960B	0.00
Hypermarcas (HYPMY)	Brazil	$2.882B	19.78
Catalyst Pharmaceuticals (CPRX)	United States	$2.854B	9.11
Dyne Therapeutics (DYN)	United States	$2.494B	0.00
Ocular Therapeutix (OCUL)	United States	$2.277B	0.00
Soleno Therapeutics (SLNO)	United States	$2.231B	0.00
Avadel Pharmaceuticals (AVDL)	Ireland	$2.100B	0.00
Aurinia Pharmaceuticals Inc (AUPH)	Canada	$2.015B	23.88
Guardian Pharmacy Services (GRDN)	United States	$1.995B	38.43
Ardelyx (ARDX)	United States	$1.788B	0.00
Harrow (HROW)	United States	$1.772B	108.73
Collegium Pharmaceutical (COLL)	United States	$1.522B	7.54
BioCryst Pharmaceuticals (BCRX)	United States	$1.494B	88.62
Oruka Therapeutics (ORKA)	United States	$1.486B	0.00
Enliven Therapeutics (ELVN)	United States	$1.485B	0.00
Amylyx Pharmaceuticals (AMLX)	United States	$1.361B	0.00
Relay Therapeutics (RLAY)	United States	$1.352B	0.00
Evotec AG (EVO)	Germany	$1.335B	0.00
Xeris Biopharma Holdings (XERS)	United States	$1.306B	0.00
Savara (SVRA)	United States	$1.174B	0.00
ARS Pharmaceuticals (SPRY)	United States	$1.125B	0.00
Cronos Group (CRON)	Canada	$1.025B	0.00
Xencor (XNCR)	United States	$1.012B	0.00
Theravance Biopharma (TBPH)	United States	$0.996B	41.81
Esperion Therapeutics (ESPR)	United States	$0.849B	0.00
KalVista Pharmaceuticals (KALV)	United States	$0.828B	0.00
Nektar Therapeutics (NKTR)	United States	$0.789B	0.00
Ironwood Pharmaceuticals (IRWD)	United States	$0.727B	17.19
Rigel Pharmaceuticals (RIGL)	United States	$0.725B	6.48
ProKidney (PROK)	United States	$0.701B	0.00
Bioventus (BVS)	United States	$0.641B	13.14
Lexeo Therapeutics (LXEO)	United States	$0.593B	0.00
Organogenesis (ORGO)	United States	$0.537B	0.00
Lyell Immunopharma (LYEL)	United States	$0.505B	0.00
Elite Pharmaceuticals (ELTP)	United States	$0.497B	0.00
Siga Technologies (SIGA)	United States	$0.472B	6.46
Zevra Therapeutics (ZVRA)	United States	$0.472B	0.00
4D Molecular Therapeutics (FDMT)	United States	$0.429B	0.00
Aquestive Therapeutics (AQST)	United States	$0.428B	0.00
Altimmune (ALT)	United States	$0.423B	0.00
Nature's Sunshine Products (NATR)	United States	$0.390B	23.25
USANA Health Sciences (USNA)	United States	$0.377B	10.51
Akebia Therapeutics (AKBA)	United States	$0.372B	0.00
Profound Medical (PROF)	Canada	$0.314B	0.00
Avalo Therapeutics (AVTX)	United States	$0.309B	0.00
Relmada Therapeutics (RLMD)	United States	$0.301B	0.00
Achieve Life Sciences (ACHV)	Canada	$0.301B	0.00
Aclaris Therapeutics (ACRS)	United States	$0.288B	0.00
Silence Therapeutics (SLN)	United Kingdom	$0.279B	0.00
OmniAb (OABI)	United States	$0.275B	0.00
Fractyl Health (GUTS)	United States	$0.274B	0.00
Heron Therapeutics (HRTX)	United States	$0.273B	0.00
Protara Therapeutics (TARA)	United States	$0.271B	0.00
Larimar Therapeutics (LRMR)	United States	$0.269B	0.00
Aldeyra Therapeutics (ALDX)	United States	$0.248B	0.00
Enlivex Therapeutics (ENLV)	Israel	$0.226B	0.00
Journey Medical (DERM)	United States	$0.210B	0.00
Galectin Therapeutics (GALT)	United States	$0.204B	0.00
VAXART, INC (VXRT)	United States	$0.192B	0.00
Tonix Pharmaceuticals Holding (TNXP)	United States	$0.192B	0.00
MediWound (MDWD)	Israel	$0.191B	0.00
Minerva Neurosciences (NERV)	United States	$0.187B	0.00
Innate Pharma SA (IPHYF)	France	$0.181B	0.00
Century Therapeutics (IPSC)	United States	$0.178B	0.00
Procaps Group, S.A (PROCF)	Luxembourg	$0.161B	0.00
AleAnna (ANNA)	United States	$0.155B	0.00
Surrozen (SRZN)	United States	$0.154B	0.00
Karyopharm Therapeutics (KPTI)	United States	$0.150B	0.00
Corbus Pharmaceuticals Holdings (CRBP)	United States	$0.140B	0.00
Prelude Therapeutics (PRLD)	United States	$0.138B	0.00
Context Therapeutics (CNTX)	United States	$0.137B	0.00
Incannex Healthcare (IXHL)	Australia	$0.135B	0.00
Inhibikase Therapeutics (IKT)	United States	$0.129B	0.00
Pyxis Oncology (PYXS)	United States	$0.128B	0.00
Verrica Pharmaceuticals (VRCA)	United States	$0.128B	0.00
Unicycive Therapeutics (UNCY)	United States	$0.126B	0.00
Avita Medical (RCEL)	United States	$0.104B	0.00
Cassava Sciences (SAVA)	United States	$0.102B	0.00
Cardiol Therapeutics (CRDL)	Canada	$0.096B	0.00
Vivani Medical (VANI)	United States	$0.093B	0.00
Champions Oncology (CSBR)	United States	$0.093B	39.53
Korro Bio (KRRO)	United States	$0.084B	0.00
Gain Therapeutics (GANX)	United States	$0.082B	0.00
PolyPid (PYPD)	Israel	$0.074B	0.00
Cumberland Pharmaceuticals (CPIX)	United States	$0.071B	59.00
Dominari Holdings (DOMH)	United States	$0.069B	0.00
Plus Therapeutics (PSTV)	United States	$0.068B	0.00
Arch Biopartners (ACHFF)	Canada	$0.067B	0.00
NRx Pharmaceuticals (NRXP)	United States	$0.066B	0.00
Metagenomi (MGX)	United States	$0.066B	0.00
Rafael Holdings (RFL)	United States	$0.064B	0.00
PMV Pharmaceuticals (PMVP)	United States	$0.062B	0.00
Assertio Holdings (ASRT)	United States	$0.060B	0.00
Lite Strategy (LITS)	United States	$0.053B	0.00
Acrivon Therapeutics (ACRV)	United States	$0.051B	0.00
Nutriband (NTRB)	United States	$0.051B	0.00
ElectroCore (ECOR)	United States	$0.051B	0.00
Lipocine (LPCN)	United States	$0.050B	0.00
Talphera (TLPH)	United States	$0.048B	0.00
Telomir Pharmaceuticals (TELO)	United States	$0.046B	0.00
FibroGen (FGEN)	United States	$0.039B	0.00
Wellgistics Health (WGRX)	United States	$0.039B	0.00
Reviva Pharmaceuticals Holdings (RVPH)	United States	$0.037B	0.00
FibroGen (KYNB)	United States	$0.037B	0.00
Jupiter Neurosciences (JUNS)	United States	$0.036B	0.00
Mural Oncology (MURA)	Ireland	$0.035B	0.00
MARKER THERAPEUTICS, INC (MRKR)	United States	$0.031B	0.00
Natural Alternatives (NAII)	United States	$0.029B	0.00
SCYNEXIS (SCYX)	United States	$0.028B	0.00
Klotho Neurosciences (KLTO)	United States	$0.025B	0.00
TherapeuticsMD (TXMD)	United States	$0.024B	0.00
Scienture Holdings (SCNX)	United States	$0.022B	0.00
Inotiv (NOTV)	United States	$0.021B	0.00
Liminatus Pharma (LIMN)	United States	$0.021B	0.00
Cosmos Health (COSM)	United States	$0.019B	0.00
VYNE Therapeutics (VYNE)	United States	$0.019B	0.00
Vivos Therapeutics (VVOS)	United States	$0.019B	0.00
Citius Pharmaceuticals (CTXR)	United States	$0.018B	0.00
Vyome Holdings (HIND)	United States	$0.018B	0.00
Iterum Therapeutics (ITRM)	Ireland	$0.017B	0.00
China SXT Pharmaceuticals (SXTC)	China	$0.017B	0.00
Mannatech (MTEX)	United States	$0.014B	0.00
Tempest Therapeutics (TPST)	United States	$0.014B	0.00
CASI Pharmaceuticals (CASI)	China	$0.013B	0.00
Phio Pharmaceuticals (PHIO)	United States	$0.013B	0.00
BioLineRx (BLRX)	Israel	$0.012B	0.00
Mangoceuticals (MGRX)	United States	$0.011B	0.00
Curanex Pharmaceuticals Inc (CURX)	United States	$0.010B	0.00
Ernexa Therapeutics (ERNA)	United States	$0.010B	0.00
Traws Pharma (TRAW)	United States	$0.010B	0.01
Addex Therapeutics (ADXN)	Switzerland	$0.010B	0.00
Quoin Pharmaceuticals (QNRX)	United States	$0.010B	0.00
BioVie (BIVI)	United States	$0.010B	0.00
Ainos (AIMD)	United States	$0.009B	0.00
Nuvilex (PMCB)	United States	$0.009B	0.00
Kiora Pharmaceuticals (KPRX)	United States	$0.008B	0.00
Biomerica (BMRA)	United States	$0.008B	0.00
TransCode Therapeutics (RNAZ)	United States	$0.007B	0.00
Heatwurx (PCSA)	United States	$0.007B	0.00
Indaptus Therapeutics (INDP)	United States	$0.007B	0.00
Alaunos Therapeutics (TCRT)	United States	$0.007B	0.00
Aptorum Group (APM)	United Kingdom	$0.007B	0.00
Redhill Biopharma (RDHL)	Israel	$0.006B	0.00
XTL Biopharmaceuticals (XTLB)	Israel	$0.006B	0.00
Sonoma Pharmaceuticals (SNOA)	United States	$0.006B	0.00
Xenetic Biosciences (XBIO)	United States	$0.005B	0.00
Salarius Pharmaceuticals (DCOY)	United States	$0.005B	0.00
Salarius Pharmaceuticals (SLRX)	United States	$0.005B	0.00
XORTX Therapeutics (XRTX)	Canada	$0.004B	0.00
Lyra Therapeutics (LYRA)	United States	$0.004B	0.00
InMed Pharmaceuticals (INM)	Canada	$0.003B	0.00
Clearmind Medicine (CMND)	Canada	$0.003B	0.00
Jaguar Animal Health (JAGX)	United States	$0.003B	0.00
60 Degrees Pharmaceuticals (SXTP)	United States	$0.002B	0.00
CDT Equity (CDT)	United States	$0.002B	0.00
Universe Pharmaceuticals INC (UPC)	China	$0.002B	0.00
Shuttle Pharmaceuticals Holdings (SHPH)	United States	$0.002B	0.00
PainReform (PRFX)	Israel	$0.002B	0.00
Galmed Pharmaceuticals (GLMD)	Israel	$0.001B	0.00
SciSparc (SPRC)	Israel	$0.001B	0.00
Aditxt (ADTX)	United States	$0.001B	0.00
Emisphere Technologies (EMIS)	United States	$0.000B	0.00
4D Pharma (LBPS)	United Kingdom	$0.000B	0.00
Patheon (PTHN)	Netherlands	$0.000B	0.00
RVL Pharmaceuticals (RVLP)	United States	$0.000B	0.00