Ionis Pharmaceuticals Net Profit Margin 2012-2025 | IONS

Current and historical net profit margin for Ionis Pharmaceuticals (IONS) from 2012 to 2025. Net profit margin can be defined as net Income as a portion of total sales revenue. Ionis Pharmaceuticals net profit margin for the three months ending September 30, 2025 was .
Ionis Pharmaceuticals Net Profit Margin Historical Data
Date TTM Revenue TTM Net Income Net Margin
2025-09-30 $0.97B $-0.26B -26.45%
2025-06-30 $0.95B $-0.27B -28.25%
2025-03-31 $0.72B $-0.46B -63.65%
2024-12-31 $0.71B $-0.45B -64.26%
2024-09-30 $0.80B $-0.36B -44.58%
2024-06-30 $0.81B $-0.37B -44.90%
2024-03-31 $0.78B $-0.38B -49.48%
2023-12-31 $0.79B $-0.37B -46.32%
2023-09-30 $0.62B $-0.41B -66.34%
2023-06-30 $0.63B $-0.31B -48.81%
2023-03-31 $0.58B $-0.33B -56.85%
2022-12-31 $0.59B $-0.27B -45.75%
2022-09-30 $0.88B $0.01B 0.91%
2022-06-30 $0.85B $-0.03B -3.18%
2022-03-31 $0.84B $0.00B -0.36%
2021-12-31 $0.81B $-0.03B -3.45%
2021-09-30 $0.66B $-0.61B -91.98%
2021-06-30 $0.69B $-0.55B -79.94%
2021-03-31 $0.71B $-0.50B -69.92%
2020-12-31 $0.73B $-0.45B -61.04%
2020-09-30 $0.93B $0.08B 8.36%
2020-06-30 $0.94B $0.13B 13.60%
2020-03-31 $0.96B $0.15B 15.95%
2019-12-31 $1.12B $0.28B 24.67%
2019-09-30 $0.82B $0.43B 52.25%
2019-06-30 $0.80B $0.40B 49.87%
2019-03-31 $0.75B $0.36B 47.74%
2018-12-31 $0.60B $0.27B 45.74%
2018-09-30 $0.58B $-0.05B -8.52%
2018-06-30 $0.55B $-0.05B -8.58%
2018-03-31 $0.54B $-0.01B -1.85%
2017-12-31 $0.51B $0.00B 0.00%
2017-09-30 $0.53B $0.06B 10.32%
2017-06-30 $0.53B $0.07B 12.36%
2017-03-31 $0.45B $0.01B 2.43%
2016-12-31 $0.37B $-0.06B -16.35%
2016-09-30 $0.24B $-0.18B -77.31%
2016-06-30 $0.18B $-0.23B -128.98%
2016-03-31 $0.26B $-0.13B -51.94%
2015-12-31 $0.28B $-0.09B -30.99%
2015-09-30 $0.32B $0.01B 4.42%
2015-06-30 $0.31B $0.02B 7.37%
2015-03-31 $0.25B $-0.03B -10.04%
2014-12-31 $0.21B $-0.04B -18.22%
2014-09-30 $0.17B $-0.09B -54.97%
2014-06-30 $0.15B $-0.09B -60.93%
2014-03-31 $0.13B $-0.09B -68.18%
2013-12-31 $0.15B $-0.06B -41.50%
2013-09-30 $0.13B $-0.04B -32.00%
2013-06-30 $0.11B $-0.05B -46.90%
2013-03-31 $0.12B $-0.04B -36.07%
2012-12-31 $0.10B $-0.07B -64.71%
2012-09-30 $0.11B $-0.08B -72.81%
2012-06-30 $0.12B $-0.07B -58.54%
2012-03-31 $0.10B $-0.09B -88.12%
2011-12-31 $0.10B $-0.09B -85.86%
2011-09-30 $0.09B $-0.08B -84.95%
2011-06-30 $0.10B $-0.06B -63.37%
2011-03-31 $0.10B $-0.07B -71.00%
2010-12-31 $0.11B $-0.06B -55.96%
2010-09-30 $0.12B $-0.06B -55.65%
2010-06-30 $0.11B $-0.06B -56.64%
2010-03-31 $0.12B $-0.04B -35.00%
2009-12-31 $0.12B $0.15B 126.23%
2009-09-30 $0.12B $0.16B 134.17%
2009-06-30 $0.12B $0.18B 143.44%
2009-03-31 $0.12B $0.17B 143.80%
2008-12-31 $0.11B $-0.02B -16.82%
2008-09-30 $0.09B $-0.02B -22.22%
2008-06-30 $0.10B $-0.13B -127.00%
2008-03-31 $0.07B $-0.13B -181.08%
2007-12-31 $0.06B $-0.14B -243.10%
2007-09-30 $0.05B $-0.14B -304.26%
2007-06-30 $0.01B $-0.05B -454.55%
2007-03-31 $0.01B $-0.04B -372.73%
2006-12-31 $0.01B $-0.05B -321.43%
2006-09-30 $0.03B $-0.04B -144.44%
2006-06-30 $0.03B $-0.04B -135.48%
2006-03-31 $0.04B $-0.06B -157.89%
2005-12-31 $0.04B $-0.07B -182.50%
2005-09-30 $0.04B $-0.12B -341.67%
2005-06-30 $0.04B $-0.14B -371.05%
2005-03-31 $0.04B $-0.15B -397.30%
2004-12-31 $0.04B $-0.14B -340.48%
2004-09-30 $0.04B $-0.11B -270.73%
2004-06-30 $0.04B $-0.10B -232.56%
2004-03-31 $0.05B $-0.10B -202.08%
2003-12-31 $0.05B $-0.10B -190.00%
2003-09-30 $0.06B $-0.09B -137.10%
2003-06-30 $0.07B $-0.08B -114.08%
2003-03-31 $0.08B $-0.08B -103.95%
2002-12-31 $0.08B $-0.07B -91.25%
2002-09-30 $0.08B $-0.07B -91.25%
2002-06-30 $0.08B $-0.07B -86.08%
2002-03-31 $0.07B $-0.07B -104.48%
2001-12-31 $0.05B $-0.08B -138.89%
2001-09-30 $0.04B $-0.07B -185.00%
2001-06-30 $0.04B $-0.07B -171.79%
2001-03-31 $0.04B $-0.06B -155.26%
2000-12-31 $0.04B $-0.06B -148.65%
2000-09-30 $0.04B $-0.06B -148.72%
2000-06-30 $0.03B $-0.06B -200.00%
2000-03-31 $0.03B $-0.07B -206.25%
1999-12-31 $0.04B $-0.06B -171.43%
1999-09-30 $0.03B $-0.06B -178.79%
1999-06-30 $0.04B $-0.05B -111.63%
1999-03-31 $0.04B $-0.05B -104.65%
1998-12-31 $0.04B $-0.04B -102.33%
1998-09-30 $0.05B $-0.04B -82.61%
1998-06-30 $0.04B $-0.04B -100.00%
1998-03-31 $0.04B $-0.03B -87.18%
1997-12-31 $0.04B $-0.03B -81.58%
1997-09-30 $0.04B $-0.03B -80.00%
1997-06-30 $0.03B $-0.03B -118.52%
1997-03-31 $0.03B $-0.03B -115.38%
1996-12-31 $0.03B $-0.03B -100.00%
1996-09-30 $0.02B $-0.02B -100.00%
1996-06-30 $0.02B $-0.02B -114.29%
1996-03-31 $0.02B $-0.02B -121.05%
1995-12-31 $0.02B $-0.02B -150.00%
1995-09-30 $0.01B $-0.03B -178.57%
1995-06-30 $0.01B $-0.02B -176.92%
1995-03-31 $0.01B $-0.02B -183.33%
1994-12-31 $0.02B $-0.02B -120.00%
1994-09-30 $0.02B $-0.02B -113.33%
1994-06-30 $0.02B $-0.02B -113.33%
1994-03-31 $0.02B $-0.02B -113.33%
1993-12-31 $0.01B $-0.02B -166.67%
1993-09-30 $0.01B $-0.02B -166.67%
1993-06-30 $0.01B $-0.02B -166.67%
1993-03-31 $0.01B $-0.02B -172.73%
1992-12-31 $0.01B $-0.02B -190.00%
1992-06-30 $0.01B $-0.01B -220.00%
1992-03-31 $0.00B $-0.01B -225.00%
Sector Industry Market Cap Revenue
Medical Medical - Drug Manufacturing $13.055B $0.705B
Ionis Pharmaceuticals discovers/develops RNA-targeted therapeutics using its proprietary antisense oligonucleotide technology. Its antisense medicines have been developed/are being developed to treat neurological, cardiovascular and specialty rare diseases.
Stock Name Country Market Cap PE Ratio
Chugai Pharmaceutical (CHGCY) Japan $100.311B 35.03
Takeda Pharmaceutical (TAK) Japan $58.739B 11.54
Zoetis (ZTS) United States $53.462B 19.73
BeOne Medicines - (ONC) Switzerland $37.951B 201.20
Sandoz Group AG (SDZNY) Switzerland $37.721B 0.00
Otsuka Holdings, - (OTSKY) $37.221B 0.00
Daiichi Sankyo, - (DSNKY) Japan $36.542B 0.00
United Therapeutics (UTHR) United States $20.394B 17.95
Shionogi (SGIOY) Japan $19.736B 15.26
Merck (MKKGY) Germany $19.561B 12.06
IPSEN (IPSEY) France $15.077B 0.00
Neurocrine Biosciences (NBIX) United States $12.457B 26.92
Summit Therapeutics (SMMT) United States $11.536B 0.00
Orion OYJ (ORINY) Finland $11.214B 19.47
Madrigal Pharmaceuticals (MDGL) United States $10.554B 0.00
Eisai (ESAIY) $9.636B 0.00
Ono Pharmaceutical (OPHLF) Japan $8.769B 20.98
Stevanato Group S.p.A (STVN) Italy $4.849B 27.14
Hikma Pharmaceuticals Plc (HKMPF) United Kingdom $4.828B 0.00
AMNEAL PHARMACEUTICALS, INC (AMRX) United States $4.659B 22.12
Crinetics Pharmaceuticals (CRNX) United States $4.363B 0.00
Indivior Pharmaceuticals (INDV) United States $4.323B 17.64
Corcept Therapeutics (CORT) United States $4.204B 45.42
NewAmsterdam Pharma (NAMS) Netherlands $3.927B 0.00
Centessa Pharmaceuticals (CNTA) United Kingdom $3.322B 0.00
Catalyst Pharmaceuticals (CPRX) United States $2.990B 9.54
Hypermarcas (HYPMY) Brazil $2.658B 18.24
Dyne Therapeutics (DYN) United States $2.220B 0.00
Guardian Pharmacy Services (GRDN) United States $2.119B 40.81
Avadel Pharmaceuticals (AVDL) Ireland $2.113B 0.00
Soleno Therapeutics (SLNO) United States $2.000B 0.00
Ocular Therapeutix (OCUL) United States $1.933B 0.00
Aurinia Pharmaceuticals Inc (AUPH) Canada $1.876B 22.23
Harrow (HROW) United States $1.766B 108.39
Ardelyx (ARDX) United States $1.669B 0.00
Enliven Therapeutics (ELVN) United States $1.586B 0.00
Oruka Therapeutics (ORKA) United States $1.559B 0.00
Definium Therapeutics (DFTX) United States $1.552B 0.00
Amylyx Pharmaceuticals (AMLX) United States $1.551B 0.00
Relay Therapeutics (RLAY) United States $1.548B 0.00
Nektar Therapeutics (NKTR) United States $1.451B 0.00
Collegium Pharmaceutical (COLL) United States $1.447B 7.17
BioCryst Pharmaceuticals (BCRX) United States $1.425B 84.50
Evotec AG (EVO) Germany $1.248B 0.00
Savara (SVRA) United States $1.139B 0.00
Xeris Biopharma Holdings (XERS) United States $1.132B 0.00
Theravance Biopharma (TBPH) United States $0.990B 41.55
Cronos Group (CRON) Canada $0.988B 0.00
Aktis Oncology (AKTS) United States $0.900B 0.00
ARS Pharmaceuticals (SPRY) United States $0.875B 0.00
Xencor (XNCR) United States $0.828B 0.00
Esperion Therapeutics (ESPR) United States $0.820B 0.00
KalVista Pharmaceuticals (KALV) United States $0.754B 0.00
Ironwood Pharmaceuticals (IRWD) United States $0.732B 17.31
Bioventus (BVS) United States $0.684B 14.02
Rigel Pharmaceuticals (RIGL) United States $0.623B 5.56
ProKidney (PROK) United States $0.596B 0.00
Lyell Immunopharma (LYEL) United States $0.549B 0.00
4D Molecular Therapeutics (FDMT) United States $0.534B 0.00
Altimmune (ALT) United States $0.511B 0.00
Siga Technologies (SIGA) United States $0.486B 6.66
Zevra Therapeutics (ZVRA) United States $0.479B 0.00
Elite Pharmaceuticals (ELTP) United States $0.474B 0.00
Organogenesis (ORGO) United States $0.473B 0.00
Nature's Sunshine Products (NATR) United States $0.471B 28.03
Lexeo Therapeutics (LXEO) United States $0.461B 0.00
Aquestive Therapeutics (AQST) United States $0.445B 0.00
USANA Health Sciences (USNA) United States $0.382B 10.66
Aclaris Therapeutics (ACRS) United States $0.346B 0.00
Protara Therapeutics (TARA) United States $0.336B 0.00
Akebia Therapeutics (AKBA) United States $0.321B 0.00
Aldeyra Therapeutics (ALDX) United States $0.318B 0.00
Cybin (HELP) Canada $0.304B 0.00
Relmada Therapeutics (RLMD) United States $0.273B 0.00
Minerva Neurosciences (NERV) United States $0.271B 0.00
Avalo Therapeutics (AVTX) United States $0.264B 0.00
Enlivex Therapeutics (ENLV) Israel $0.263B 0.00
Larimar Therapeutics (LRMR) United States $0.261B 0.00
Journey Medical (DERM) United States $0.257B 0.00
OmniAb (OABI) United States $0.245B 0.00
Profound Medical (PROF) Canada $0.240B 0.00
Achieve Life Sciences (ACHV) Canada $0.224B 0.00
MediWound (MDWD) Israel $0.222B 0.00
Context Therapeutics (CNTX) United States $0.211B 0.00
Heron Therapeutics (HRTX) United States $0.211B 0.00
Silence Therapeutics (SLN) United Kingdom $0.210B 0.00
Surrozen (SRZN) United States $0.210B 0.00
Tonix Pharmaceuticals Holding (TNXP) United States $0.184B 0.00
Innate Pharma SA (IPHYF) France $0.181B 0.00
Galectin Therapeutics (GALT) United States $0.178B 0.00
AleAnna (ANNA) United States $0.171B 0.00
Karyopharm Therapeutics (KPTI) United States $0.157B 0.00
Century Therapeutics (IPSC) United States $0.153B 0.00
Prelude Therapeutics (PRLD) United States $0.140B 0.00
VAXART, INC (VXRT) United States $0.136B 0.00
Unicycive Therapeutics (UNCY) United States $0.133B 0.00
Corbus Pharmaceuticals Holdings (CRBP) United States $0.133B 0.00
Avita Medical (RCEL) United States $0.127B 0.00
Inhibikase Therapeutics (IKT) United States $0.126B 0.00
Cardiol Therapeutics (CRDL) Canada $0.116B 0.00
Korro Bio (KRRO) United States $0.105B 0.00
Cassava Sciences (SAVA) United States $0.101B 0.00
Incannex Healthcare (IXHL) Australia $0.093B 0.00
Vivani Medical (VANI) United States $0.092B 0.00
Verrica Pharmaceuticals (VRCA) United States $0.091B 0.00
Champions Oncology (CSBR) United States $0.084B 35.76
Pyxis Oncology (PYXS) United States $0.081B 0.00
Assertio Holdings (ASRT) United States $0.079B 0.00
PolyPid (PYPD) Israel $0.070B 0.00
Gain Therapeutics (GANX) United States $0.070B 0.00
HST Global (HSTC) United States $0.069B 0.00
Rafael Holdings (RFL) United States $0.062B 0.00
PMV Pharmaceuticals (PMVP) United States $0.059B 0.00
Cumberland Pharmaceuticals (CPIX) United States $0.058B 48.50
Fractyl Health (GUTS) United States $0.057B 0.00
BioNxt Solutions (BNXTF) Canada $0.057B 0.00
Procaps Group, S.A (PROCF) Luxembourg $0.056B 0.00
Dominari Holdings (DOMH) United States $0.055B 0.00
NRx Pharmaceuticals (NRXP) United States $0.053B 0.00
Acrivon Therapeutics (ACRV) United States $0.051B 0.00
Nutriband (NTRB) United States $0.050B 0.00
Lipocine (LPCN) United States $0.048B 0.00
ElectroCore (ECOR) United States $0.043B 0.00
Lite Strategy (LITS) United States $0.041B 0.00
FibroGen (FGEN) United States $0.039B 0.00
Plus Therapeutics (PSTV) United States $0.038B 0.00
Talphera (TLPH) United States $0.038B 0.00
Telomir Pharmaceuticals (TELO) United States $0.037B 0.00
Mural Oncology (MURA) Ireland $0.035B 0.00
SCYNEXIS (SCYX) United States $0.031B 0.00
Reviva Pharmaceuticals Holdings (RVPH) United States $0.030B 0.00
TherapeuticsMD (TXMD) United States $0.027B 0.00
Wellgistics Health (WGRX) United States $0.025B 0.00
MARKER THERAPEUTICS, INC (MRKR) United States $0.024B 0.00
Natural Alternatives (NAII) United States $0.022B 0.00
Jupiter Neurosciences (JUNS) United States $0.020B 0.00
VYNE Therapeutics (VYNE) United States $0.019B 0.00
Phio Pharmaceuticals (PHIO) United States $0.018B 0.00
Scienture Holdings (SCNX) United States $0.018B 0.00
Klotho Neurosciences (KLTO) United States $0.016B 0.00
Citius Pharmaceuticals (CTXR) United States $0.016B 0.00
Traws Pharma (TRAW) United States $0.015B 0.02
Iterum Therapeutics (ITRM) Ireland $0.015B 0.00
Vyome Holdings (HIND) United States $0.015B 0.00
Cosmos Health (COSM) United States $0.014B 0.00
Vivos Therapeutics (VVOS) United States $0.014B 0.00
Mannatech (MTEX) United States $0.014B 0.00
BioLineRx (BLRX) Israel $0.013B 0.00
Liminatus Pharma (LIMN) United States $0.012B 0.00
Tempest Therapeutics (TPST) United States $0.012B 0.00
CASI Pharmaceuticals (CASI) China $0.010B 0.00
Inotiv (NOTV) United States $0.010B 0.00
BioVie (BIVI) United States $0.010B 0.00
Addex Therapeutics (ADXN) Switzerland $0.009B 0.00
TransCode Therapeutics (RNAZ) United States $0.008B 0.00
Curanex Pharmaceuticals Inc (CURX) United States $0.008B 0.00
XTL Biopharmaceuticals (XTLB) Israel $0.008B 0.00
Kiora Pharmaceuticals (KPRX) United States $0.008B 0.00
Ainos (AIMD) United States $0.007B 0.00
Quoin Pharmaceuticals (QNRX) United States $0.007B 0.00
Biomerica (BMRA) United States $0.007B 0.00
Nuvilex (PMCB) United States $0.007B 0.00
Mangoceuticals (MGRX) United States $0.006B 0.00
Alaunos Therapeutics (TCRT) United States $0.006B 0.00
Redhill Biopharma (RDHL) Israel $0.005B 0.00
Heatwurx (PCSA) United States $0.005B 0.00
Xenetic Biosciences (XBIO) United States $0.005B 0.00
Aptorum Group (APM) United Kingdom $0.005B 0.00
Salarius Pharmaceuticals (SLRX) United States $0.005B 0.00
Sonoma Pharmaceuticals (SNOA) United States $0.005B 0.00
Indaptus Therapeutics (INDP) United States $0.004B 0.00
60 Degrees Pharmaceuticals (SXTP) United States $0.004B 0.00
Galmed Pharmaceuticals (GLMD) Israel $0.003B 0.00
XORTX Therapeutics (XRTX) Canada $0.003B 0.00
InMed Pharmaceuticals (INM) Canada $0.003B 0.00
Ernexa Therapeutics (ERNA) United States $0.003B 0.00
China SXT Pharmaceuticals (SXTC) China $0.003B 0.00
Lyra Therapeutics (LYRA) United States $0.002B 0.00
Jaguar Animal Health (JAGX) United States $0.002B 0.00
SciSparc (SPRC) Israel $0.002B 0.00
Shuttle Pharmaceuticals Holdings (SHPH) United States $0.002B 0.00
CDT Equity (CDT) United States $0.002B 0.00
Clearmind Medicine (CMND) Canada $0.002B 0.00
Universe Pharmaceuticals INC (UPC) China $0.002B 0.00
PainReform (PRFX) Israel $0.001B 0.00
Aditxt (ADTX) United States $0.000B 0.00
Emisphere Technologies (EMIS) United States $0.000B 0.00
Grifols, S.A (GRFS) Spain $0.000B 0.00
4D Pharma (LBPS) United Kingdom $0.000B 0.00
Patheon (PTHN) Netherlands $0.000B 0.00
RVL Pharmaceuticals (RVLP) United States $0.000B 0.00