The current metro area population of Santiago de Cuba in 2025 is 443,000, a 0.23% increase from 2024.

• The metro area population of Santiago de Cuba in 2024 was 442,000, a 0.23% increase from 2023.
• The metro area population of Santiago de Cuba in 2023 was 441,000, a 0.23% increase from 2022.
• The metro area population of Santiago de Cuba in 2022 was 440,000, a 0.23% increase from 2021.